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本文引用的文献
1
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J Am Chem Soc. 2010 Oct 13;132(40):14229-38. doi: 10.1021/ja106175q.
2
An Alkoxide Anion Triggered tert-Butyloxycarbonyl Group Migration. Mechanism and Application.
Tetrahedron Lett. 2010 May 5;51(18):2536-2538. doi: 10.1016/j.tetlet.2010.03.009.
3
Potent and selective neuronal nitric oxide synthase inhibitors with improved cellular permeability.
Bioorg Med Chem Lett. 2010 Jan 15;20(2):554-7. doi: 10.1016/j.bmcl.2009.11.086. Epub 2009 Nov 22.
4
Analogues of 2-aminopyridine-based selective inhibitors of neuronal nitric oxide synthase with increased bioavailability.
Bioorg Med Chem. 2009 Mar 15;17(6):2371-80. doi: 10.1016/j.bmc.2009.02.017. Epub 2009 Feb 14.
5
Selective neuronal nitric oxide synthase inhibitors and the prevention of cerebral palsy.
Ann Neurol. 2009 Feb;65(2):209-17. doi: 10.1002/ana.21555.
6
Role of nitric oxide in Parkinson's disease.
Pharmacol Ther. 2006 Jan;109(1-2):33-41. doi: 10.1016/j.pharmthera.2005.05.007. Epub 2005 Jul 7.
7
General method for the palladium-catalyzed allylation of aliphatic alcohols.
J Org Chem. 2003 Oct 17;68(21):8092-6. doi: 10.1021/jo0301907.
8
Decreased neuronal nitric oxide synthase messenger RNA and somatostatin messenger RNA in the striatum of Huntington's disease.
Neuroscience. 1996 Jun;72(4):1037-47. doi: 10.1016/0306-4522(95)00596-x.
9
Nitric oxide synthase activity is elevated in brain microvessels in Alzheimer's disease.
Biochem Biophys Res Commun. 1994 Nov 30;205(1):659-65. doi: 10.1006/bbrc.1994.2716.
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