Peng Yanbo, Wang Dali, Zhang Jiang, Xue Xinhong, Wang Zhuo, Tong Weijun, Xu Tan, Zhang Yonghong
Department of Epidemiology, School of Radiation Medicine and Public Health, Medical College of Soochow University, Suzhou, China.
Clin Invest Med. 2011 Aug 1;34(4):E249. doi: 10.25011/cim.v34i4.15368.
We studied the association between admission white blood cell (WBC) count and short term outcome in patients with acute cerebral infarction.
2808 patients with acute cerebral infarction were included in the study. WBC count and other variables were collected within the first 24 hours of admission. Clinical outcomes (death or dependency) were evaluated by neurologists during hospitalization. The associations between WBC count and in-hospital death or dependency at discharge were analyzed using a multiple logistic model.
Multivariate-adjusted odds ratio (95% confidence intervals) of dependency associated with patients with WBC of 10.0-10.9×109/L, 11.0-11.9×109/L, ≥12.0×109/L were 1.46(0. 87-2. 45), 6.21(3. 70-10. 42) and 7.01(4. 53-10. 87), respectively, when compared with patients with admission WBC counts < 10.0x109/L. Multivariate-adjusted odds ratio (95% confidence intervals) of death associated with WBC 10.0-10.9×109/L, 11.0-11.9×109/L and ≥12.0×109/L were 2.098(0. 96-4. 58), 4.79(2. 24-10. 22) and 5.59(3. 14-9. 98), respectively.
Increased WBC count at admission was significantly and positively associated with in-hospital death or dependency at discharge among patients with acute cerebral infarction.
我们研究了急性脑梗死患者入院时白细胞（WBC）计数与短期预后之间的关联。
2808例急性脑梗死患者纳入本研究。在入院后的头24小时内收集白细胞计数及其他变量。住院期间由神经科医生评估临床结局（死亡或依赖）。使用多元逻辑模型分析白细胞计数与住院死亡或出院时依赖之间的关联。
与入院时白细胞计数<10.0×10⁹/L的患者相比，白细胞计数为10.0 - 10.9×10⁹/L、11.0 - 11.9×10⁹/L、≥12.0×10⁹/L的患者发生依赖的多因素调整优势比（95%置信区间）分别为1.46（0.87 - 2.45）、6.21（3.70 - 10.42）和7.01（4.53 - 10.87）。白细胞计数为10.0 - 10.9×10⁹/L、11.0 - 11.9×10⁹/L和≥12.0×10⁹/L的患者死亡的多因素调整优势比（95%置信区间）分别为2.098（0.96 - 4.58）、4.79（2.24 - 10.22）和5.59（3.14 - 9.98）。
急性脑梗死患者入院时白细胞计数升高与住院死亡或出院时依赖显著正相关。
