Becker E L
Department of Pathology, University of Connecticut Health Center, Farmington 06032.
J Leukoc Biol. 1990 Apr;47(4):378-89. doi: 10.1002/jlb.47.4.378.
This is largely a history of attempts from approximately 1960 until about 1980-81 to understand the mechanisms by which neutrophils are activated by chemotactic factors to induce chemotaxis and granule secretion. As such, it deals with the growth of our knowledge of neutrophil chemotactic factors and their receptors; the importance and role of cation fluxes, especially Ca2+, microfilaments and microtubules, membrane potential, cyclic nucleotides, and the start of our recognition of the importance of arachidonic acid and phospholipid metabolism and protein phosphorylation. In a very real sense this is a history of the origins of our present realization that reactions and functions which had been considered specific to the neutrophil are to be thought of as similar or identical to general biological and physiological processes such as muscle contraction, cellular secretion, etc.
这主要是一段关于从大约1960年到1980 - 1981年期间，人们试图理解中性粒细胞被趋化因子激活从而诱导趋化作用和颗粒分泌的机制的历史。因此，它涉及我们对中性粒细胞趋化因子及其受体的认识的发展；阳离子通量，特别是Ca2+、微丝和微管、膜电位、环核苷酸的重要性和作用，以及我们开始认识到花生四烯酸和磷脂代谢以及蛋白质磷酸化的重要性。从非常实际的意义上讲，这是一段历史，它让我们认识到，那些曾被认为是中性粒细胞特有的反应和功能，现在应被视为与肌肉收缩、细胞分泌等一般生物学和生理过程相似或相同。
