Jin Nan, Zhao Yong-Xing, Deng Shu-Hua, Sun Qian
School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, PR China.
Pharmazie. 2011 Jul;66(7):506-10.
The aim of this study was to prepare oxymatrine (OMT) mixed micellar nanoparticles to delay release of the drug and enhance its cytotoxicity against cancer cells. A co-solvent evaporation method using lipoid E80, lipoid S75, MPEG-PLA and Poloxamer 188 was chosen to prepare the OMT formulation, and its release characteristics, cytotoxic activity in vitro and physical characteristics were evaluated. The results showed that OMT mixed micellar nanoparticles have sustained release and cytotoxic activity in vitro to the SMMC-7721 cell line.
本研究的目的是制备氧化苦参碱（OMT）混合胶束纳米粒，以延缓药物释放并增强其对癌细胞的细胞毒性。采用共溶剂蒸发法，使用Lipoid E80、Lipoid S75、MPEG-PLA和泊洛沙姆188制备OMT制剂，并对其释放特性、体外细胞毒性活性和物理特性进行评价。结果表明，OMT混合胶束纳米粒对SMMC-7721细胞系具有缓释和体外细胞毒性活性。
