Department of Nephrology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Lupus. 2011 Dec;20(14):1541-6. doi: 10.1177/0961203311409274. Epub 2011 Aug 3.
The pathogenesis of systemic lupus erythematosus (SLE) has been attributed to complex interactions between genetic, hormonal and environmental factors. The influence of a genetic predisposition to SLE is supported by family aggregation and a high concordance rate in monozygotic twins. Here we present a rare case of simultaneous presentation of SLE and lupus nephritis in a mother and son. Both patients had nephrotic-range proteinuria, and the renal pathological classifications of the son and his mother were Class IV-G (A) and Class III (A/C), respectively, according to the International Society of Nephrology/Renal Pathology Society (ISN/RPS) 2003 classification of lupus nephritis. Apart from the renal involvement, both patients had leucopenia and anemia, and the mother also had typical cutaneous lesions and secondary Sjögren's syndrome. This case supports the genetic role in the etiology of SLE, and displayed different clinical presentations and disease severity in familial SLE patients of different gender and age.
系统性红斑狼疮（SLE）的发病机制归因于遗传、激素和环境因素之间的复杂相互作用。遗传易感性对SLE 的影响得到了家族聚集性和同卵双胞胎高度一致性的支持。在这里，我们报告了一例罕见的母亲和儿子同时出现SLE 和狼疮性肾炎的病例。两位患者均有肾病范围蛋白尿，根据国际肾脏病学会/肾脏病理学会（ISN/RPS）2003 年狼疮肾炎分类，儿子和他母亲的肾脏病理分类分别为 IV-G（A）和 III（A/C）。除了肾脏受累外，两位患者均有白细胞减少和贫血，母亲还伴有典型的皮肤病变和继发性干燥综合征。该病例支持遗传在SLE 病因学中的作用，并在不同性别和年龄的家族性 SLE 患者中显示出不同的临床表现和疾病严重程度。
