视网膜萎缩与恢复性视神经炎患者 fMRI 反应相关。
Retinal atrophy correlates with fMRI response in patients with recovered optic neuritis.
机构信息
Functional Imaging Unit, Department of Clinical Physiology and Nuclear Medicine, Glostrup Hospital, University of Copenhagen, Denmark.
出版信息
Neurology. 2011 Aug 16;77(7):645-51. doi: 10.1212/WNL.0b013e3182299e36. Epub 2011 Aug 3.
OBJECTIVE
We wanted to investigate if retinal nerve fiber layer thickness (RNFLT) measured by optical coherence tomography (OCT) might be a good marker of acute and chronic changes in the afferent visual pathway following acute optic neuritis (ON).
METHODS
We studied the relationship of optic nerve lesion length, optic nerve mean area, and RNFLT, quantified by OCT, with fMRI response to a visual paradigm in 40 patients with acute ON and 19 healthy controls in a prospective cohort study over a 6-month period.
RESULTS
The main finding was a significant correlation of optic nerve lesion length and mean area with fMRI response in affected eyes in the acute phase and between RNFLT and fMRI response in affected eyes after recovery.
CONCLUSION
RNFLT is a very good measure of damage to the afferent visual pathway in recovered patients with ON and should be included in future fMRI studies when looking for visual reorganization in recovered patients with ON.
目的
我们旨在研究光学相干断层扫描（OCT）测量的视网膜神经纤维层厚度（RNFLT）是否可能成为急性视神经炎（ON）后传入视觉通路急性和慢性变化的良好标志物。
方法
我们通过前瞻性队列研究，在 6 个月的时间内，研究了 40 例急性 ON 患者和 19 名健康对照者的视神经病变长度、视神经平均面积和 OCT 定量的 RNFLT 与视觉范式 fMRI 反应之间的关系。
结果
主要发现是在急性期，视神经病变长度和平均面积与受累眼的 fMRI 反应显著相关，而在恢复期，RNFLT 与受累眼的 fMRI 反应相关。
结论
在恢复的 ON 患者中，RNFLT 是评估传入视觉通路损伤的一个非常好的指标，在未来的 fMRI 研究中，应该将其纳入对恢复的 ON 患者进行视觉重组的研究中。
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