基质金属蛋白酶-9、IV 型胶原和血管内皮生长因子在造釉细胞瘤中的表达。
Expression of matrix metalloproteinase-9, type IV collagen and vascular endothelial growth factor in adamantinous craniopharyngioma.
机构信息
Department of Neurosurgery, Yulin Number 2 Hospital, Yulin, China.
出版信息
Neurochem Res. 2011 Dec;36(12):2346-51. doi: 10.1007/s11064-011-0560-9. Epub 2011 Aug 4.
To explore the expression of matrix metalloproteinase 9 (MMP-9), type IV collagen (Col IV) and vascular endothelial growth factor (VEGF) in adamantinomatous craniopharyngioma (ACP) and analyze the correlation between the level of these markers and adamantimous craniopharyngiomas recurrence. Expressions of MMP-9, Col IV and VEGF were tested by immunohistochemistry (IHC) in 40 cases of ACP, including 24 cases of primary group and 16 cases of recurred group. The expression level of MMP-9 and VEGF in recurred group were significantly higher than primary group (93.7% vs. 41.7%, P < 0.05, 87.5% vs. 45.8%, P < 0.05, respectively). The expression of Col IV in the recurred group was significant different from the primary group (Z = -2.619, P < 0.05). MMP-9, Col IV and VEGF may be the potential specific bio-marker related to the recurrence of ACP.
目的
探讨基质金属蛋白酶 9（MMP-9）、IV 型胶原（Col IV）和血管内皮生长因子（VEGF）在造釉细胞瘤型颅咽管瘤（ACP）中的表达，并分析这些标志物水平与造釉细胞瘤型颅咽管瘤复发的相关性。
方法
采用免疫组织化学（IHC）方法检测 40 例 ACP 患者[包括初发组 24 例和复发组 16 例]中 MMP-9、Col IV 和 VEGF 的表达。结果：复发组 MMP-9 和 VEGF 的表达水平显著高于初发组（93.7%比 41.7%，P<0.05；87.5%比 45.8%，P<0.05）。复发组 Col IV 的表达与初发组差异有统计学意义（Z=-2.619，P<0.05）。
结论
MMP-9、Col IV 和 VEGF 可能是与 ACP 复发相关的潜在特异性生物标志物。
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