Strong P N
Jerry Lewis Muscle Research Centre, Department of Paediatrics and Neonatal Medicine, Royal Postgraduate Medical School, London, U.K.
Pharmacol Ther. 1990;46(1):137-62. doi: 10.1016/0163-7258(90)90040-9.
Many venom toxins interfere with ion channel function. Toxins, as specific, high affinity ligands, have played an important part in purifying and characterizing many ion channel proteins. Our knowledge of potassium ion channel structure is meager because until recently, no specific potassium channel toxins were known, or identified as such. This review summarizes the sudden explosion of research on potassium channel toxins that has occurred in recent years. Toxins are discussed in terms of their structure, physiological and pharmacological properties, and the characterization of toxin binding sites on different subtypes of potassium ion channels.
许多毒液毒素会干扰离子通道功能。毒素作为特异性、高亲和力的配体，在纯化和鉴定许多离子通道蛋白方面发挥了重要作用。我们对钾离子通道结构的了解很少，因为直到最近，还没有已知的或被鉴定为特异性的钾通道毒素。这篇综述总结了近年来关于钾通道毒素研究的突然激增。本文将从毒素的结构、生理和药理特性以及钾离子通道不同亚型上毒素结合位点的鉴定等方面对毒素进行讨论。
