Van Hong N T, Rivière Céline, Hong Quang T, Chataigné Gabrielle, Hoai Nam N, Dejaegher Bieke, Tistaert Christophe, Kim Thanh N T, Van Kiem P, Vander Heyden Yvan, Van Minh C, Quetin-Leclercq Joëlle
Institute of Natural Products Chemistry, Hoang Quoc Viet Road, Nghia Do Cau Giay, 18, Vietnam Academy of Science and Technology, Hanoi, Vietnam.
Nat Prod Commun. 2011 Jun;6(6):813-8.
Several Mallotus species (Euphorbiaceae) are used in Vietnam as edible plants or as traditional medicines for different indications, some related to the treatment of inflammatory diseases. This study investigated the antioxidant activities of 33 samples from 17 Vietnamese Mallotus species. We also evaluated potential cytotoxic activity against human cervix carcinoma HeLa and human lung fibroblast WI-38 cells. Our aim is to develop safe dietary supplements with a protective effect against various diseases caused by tissue damage and the acceleration of the aging process linked to reactive oxygen species. These tests allowed the identification of non-cytotoxic plant species exhibiting significant antiradical properties. These antioxidant properties may be explained by their polyphenol composition. The antioxidant activity of the most active Mallotus species was further analyzed with and without tannins removal. We also identified by LC-ESI-MS some flavonoids responsible for a part of this activity.
越南的几种野桐属植物（大戟科）被用作可食用植物或用于治疗不同病症的传统药物，其中一些与炎症性疾病的治疗有关。本研究调查了越南17种野桐属植物的33个样本的抗氧化活性。我们还评估了其对人宫颈癌HeLa细胞和人肺成纤维细胞WI-38的潜在细胞毒性活性。我们的目标是开发对由组织损伤和与活性氧相关的衰老过程加速所引起的各种疾病具有保护作用的安全膳食补充剂。这些测试使得能够鉴定出具有显著抗自由基特性的无细胞毒性植物物种。这些抗氧化特性可能由其多酚成分来解释。对活性最高的野桐属植物在去除和未去除单宁的情况下进一步分析了其抗氧化活性。我们还通过液相色谱-电喷雾电离质谱法鉴定了部分导致这种活性的黄酮类化合物。
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