Dani Carlo
Department of Medical and Surgical Critical Care, Section of Neonatology, Careggi University Hospital of Florence, Firenze, Italy.
J Matern Fetal Neonatal Med. 2011 Nov;24 Suppl 3:5-6. doi: 10.3109/14767058.2011.607955. Epub 2011 Oct 13.
A high percentage of preterm infants fails to respond to a single course of indomethacin or ibuprofen. Thus, it has been suggested that the actual dose regimens of these drugs could be inadequate because of large interindividual pharmacokinetics variations in premature infants. We tested the hypothesis that a high-dose regimen of ibuprofen was more effective than the current regimen in closing PDA. We demonstrated that a single course of ibuprofen at 20-10-10 mg/kg/day is more effective than a 10-5-5 mg/kg/day course in closing PDA without significant adverse effects. Many other questions regarding the pharmacological treatment of PDA are still debated.
很大比例的早产儿对单疗程的吲哚美辛或布洛芬无反应。因此，有人提出，由于早产儿个体间药代动力学差异较大，这些药物的实际给药方案可能并不充分。我们检验了这样一个假设，即高剂量布洛芬方案在关闭动脉导管未闭（PDA）方面比当前方案更有效。我们证明，以20 - 10 - 10毫克/千克/天的剂量单疗程使用布洛芬在关闭PDA方面比10 - 5 - 5毫克/千克/天的疗程更有效，且无明显不良反应。关于PDA药物治疗的许多其他问题仍存在争议。
