可溶性尿激酶型纤溶酶原激活物受体在全身炎症反应综合征中的诊断和预后意义。
The diagnostic and prognostic significance of soluble urokinase plasminogen activator receptor in systemic inflammatory response syndrome.
机构信息
Department of Infectious Diseases and Clinical Microbiology, Medical Faculty, Karadeniz Technical University, Trabzon, Turkey.
出版信息
Clin Biochem. 2011 Oct;44(14-15):1227-30. doi: 10.1016/j.clinbiochem.2011.07.006. Epub 2011 Jul 26.
OBJECTIVES
This study was intended to investigate the value of suPAR, C-reactive protein (CRP) and procalcitonin (PCT) in the determination and prognosis of systemic inflammatory response syndrome (SIRS) patients.
METHODS
The study was performed among patients with at least two SIRS criteria. PCT, CRP and suPAR were analyzed from the blood specimens taken.
RESULTS
Eighty-five patients were enrolled in the SIRS group (44 bacteremia, 20 urinary tract infection, 12 pneumonia and 9 non-infection), and 53 individuals in the control group. A significant correlation was determined between suPAR, PCT and CRP values in both groups (P<0.0001). A suPAR cutoff value of 2.8ng/mL was associated with an NPV of 87% and PPV of 91%, with 92% sensitivity and 85% specificity. A relatively high suPAR level that might predict fatality was also determined in fatal cases (P=0.001).
CONCLUSION
suPAR possesses high sensitivity and specificity levels in terms of differential diagnosis, and high suPAR levels can predict fatality.
目的
本研究旨在探讨可溶性尿激酶型纤溶酶原激活物受体（suPAR）、C 反应蛋白（CRP）和降钙素原（PCT）在全身炎症反应综合征（SIRS）患者的诊断和预后评估中的价值。
方法
本研究纳入至少符合 2 项 SIRS 标准的患者。从采集的血标本中分析 PCT、CRP 和 suPAR。
结果
SIRS 组 85 例（菌血症 44 例、尿路感染 20 例、肺炎 12 例、非感染 9 例），对照组 53 例。两组 suPAR、PCT 和 CRP 值之间存在显著相关性（P<0.0001）。suPAR 截断值为 2.8ng/mL 时，其阴性预测值为 87%，阳性预测值为 91%，敏感性为 92%，特异性为 85%。在死亡病例中也确定了较高的 suPAR 水平，可能预示着病死率（P=0.001）。
结论
suPAR 在鉴别诊断方面具有较高的敏感性和特异性，且高水平 suPAR 可预测病死率。
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