在运动药物检测中检测到 SARM-S4 及其代谢物：案例报告。

SARM-S4 and metabolites detection in sports drug testing: a case report.

机构信息

Swiss Laboratory for Doping Analyses, University Center of Legal Medecine, Geneva and Lausanne, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Ch. des Croisettes 22, 1066 Epalinges, Switzerland.

出版信息

Forensic Sci Int. 2011 Dec 10;213(1-3):104-8. doi: 10.1016/j.forsciint.2011.07.014. Epub 2011 Aug 3.

DOI:10.1016/j.forsciint.2011.07.014

PMID:21816554

Abstract

Recently, pharmaceutical industry developed a new class of therapeutics called Selective Androgen Receptor Modulator (SARM) to substitute the synthetic anabolic drugs used in medical treatments. Since the beginning of the anti-doping testing in sports in the 1970s, steroids have been the most frequently detected drugs mainly used for their anabolic properties. The major advantage of SARMs is the reduced androgenic activities which are the main source of side effects following anabolic agents' administration. In 2010, the Swiss laboratory for doping analyses reported the first case of SARMs abuse during in-competition testing. The analytical steps leading to this finding are described in this paper. Screening and confirmation results were obtained based on liquid chromatography tandem mass spectrometry (LC-MS/MS) analyses. Additional information regarding the SARM S-4 metabolism was investigated by ultra high-pressure liquid chromatography coupled to quadrupole time-of-flight mass spectrometer (UHPLC-QTOF-MS).

摘要

最近，制药行业开发了一类新的治疗药物，称为选择性雄激素受体调节剂（SARM），以替代用于医疗的合成合成代谢药物。自 20 世纪 70 年代开始在体育运动中进行反兴奋剂检测以来，类固醇一直是最常被检测到的药物，主要用于其合成代谢特性。SARM 的主要优点是雄激素活性降低，这是使用合成代谢药物后产生副作用的主要原因。2010 年，瑞士兴奋剂分析实验室报告了首例在比赛中滥用 SARM 的案例。本文描述了得出这一发现的分析步骤。基于液相色谱串联质谱（LC-MS/MS）分析，获得了筛选和确认结果。通过超高效液相色谱-四极杆飞行时间质谱（UHPLC-QTOF-MS）进一步研究了 SARM S-4 的代谢情况。