MR 引导的门静脉递送和磁胶囊监测：对肝脏生理影响的评估。
MR-guided portal vein delivery and monitoring of magnetocapsules: assessment of physiologic effects on the liver.
机构信息
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
出版信息
J Vasc Interv Radiol. 2011 Sep;22(9):1335-40. doi: 10.1016/j.jvir.2011.03.024. Epub 2011 Aug 4.
PURPOSE
The authors previously developed magnetic resonance (MR)-trackable magnetocapsules (MCs) that can simultaneously immunoprotect human islet cells and noninvasively monitor portal delivery and engraftment in real time with MR imaging. This study was designed to assess the physiologic effects of the delivery of a clinical dose of MCs (140,000 capsules) into the portal vein (PV) in swine over a 1-month period.
MATERIALS AND METHODS
MCs were formed by using clinical-grade alginate mixed with a clinically applicable dosage of ferumoxide. Percutaneous access into the PV was obtained by using a custom-built, MR-trackable needle, and 140,000 MCs were delivered under MR guidance in five swine. Portal pressures and liver function data were obtained over a 4-week period.
RESULTS
A transient increase in portal pressure occurred immediately after MC delivery that returned to normal levels by 4 weeks after MC delivery. Liver function test results were normal during the entire period, and the appearance of the MCs on MR imaging did not change.
CONCLUSIONS
A clinically applicable dose of 140,000 MCs has no adverse effects on portal pressures or liver function in this normal swine model during the first month after delivery.
目的
作者先前开发了可同时免疫保护人胰岛细胞并通过磁共振成像（MRI）实时非侵入性监测门脉递送和植入的磁共振（MR）可追踪磁胶囊（MC）。本研究旨在评估在 1 个月的时间内将临床剂量的 MC（140,000 个胶囊）递送到猪门静脉（PV）中的生理影响。
材料和方法
使用临床级海藻酸钠和临床适用剂量的超顺磁性氧化铁制成 MC。通过定制的、MR 可追踪的针获得 PV 的经皮进入，在 5 头猪中在 MR 引导下递送 140,000 个 MC。在 4 周的时间内获得门静脉压力和肝功能数据。
结果
MC 给药后立即出现门静脉压力短暂升高，给药后 4 周恢复正常水平。整个期间肝功能检查结果正常，MC 在 MR 成像上的外观没有变化。
结论
在递送后第一个月的正常猪模型中，临床适用剂量的 140,000 MC 对门静脉压力或肝功能没有不良影响。
Zotero 插件