Donatucci C F, Deshon G E, Wade C E, Hunt M
Department of Surgery, Letterman Army Medical Center, San Francisco, California.
Urology. 1990 Apr;35(4):295-300. doi: 10.1016/0090-4295(90)80148-g.
Furosemide remains the drug of choice for patients with the transurethral resection syndrome. Furosemide is often used intraoperatively to treat patients suspected of having excessive irrigant absorption. To examine the efficacy of such therapy, a randomized study was performed in which furosemide was administered to patients undergoing routine transurethral resection of the prostate (TURP) to determine the effect of furosemide on electrolyte and fluid volume conservation in these patients. Seven patients treated with furosemide on completion of TURP had a statistically significant delayed drop in serum sodium values after normal initial values (139 mEq/L to 134 mEq/L). Seven untreated control patients did not have a similar drop in sodium values, and the difference between groups was significant. We suggest that furosemide be used with caution in patients undergoing routine TURP, and when given it should be accompanied by the infusion of an isotonic balanced salt solution.
速尿仍是经尿道切除综合征患者的首选药物。速尿常用于术中治疗疑似灌洗液吸收过多的患者。为了检验这种治疗方法的疗效，进行了一项随机研究，在接受常规经尿道前列腺切除术（TURP）的患者中使用速尿，以确定速尿对这些患者电解质和液体量维持的影响。七名在TURP完成后接受速尿治疗的患者，血清钠值在初始正常水平（139 mEq/L降至134 mEq/L）后出现统计学上显著的延迟下降。七名未治疗的对照患者钠值没有类似下降，两组之间的差异显著。我们建议在接受常规TURP的患者中谨慎使用速尿，给药时应同时输注等渗平衡盐溶液。
