麻醉对大鼠离体脊髓中虚构运动的影响。
Anesthetic effects on fictive locomotion in the rat isolated spinal cord.
作者信息
Jinks Steven L, Andrada Jason, Satter Omar
机构信息
Department of Anesthesiology and Pain Medicine, University of California, Davis, California 95616, USA.
出版信息
Neuroreport. 2011 Sep 14;22(13):655-9. doi: 10.1097/WNR.0b013e32834a20f2.
General anesthetic mechanisms are poorly understood. Anesthetic immobilizing effects occur in the spinal ventral horn. However, a detailed analysis of anesthetic effects on ventral motor networks is lacking. We delivered isoflurane, desflurane, or propofol during NMDA/5-HT-induced, or noxious tail stimulus-evoked, fictive locomotion in neonatal rat isolated spinal cords. Anesthetics changed the frequency, amplitude, and regularity of fictive locomotion with little effect on phase-lag. Isoflurane abolished pharmacologically-induced versus noxious stimulus-induced motor output at similar concentrations. Propofol abolished pharmacologically-induced fictive locomotion through a γ-aminobutyric acid type A-receptor mechanism. Anesthetic effects on pharmacologically-elicted fictive locomotion appear clinically-relevant, and support a ventral horn immobilizing effect on locomotor rhythm generation.
全身麻醉机制尚未完全明确。麻醉的制动作用发生在脊髓腹角。然而，目前缺乏对麻醉对腹侧运动网络影响的详细分析。我们在新生大鼠离体脊髓中，于NMDA/5-羟色胺诱导的或有害尾部刺激诱发的模拟运动期间，给予异氟烷、地氟烷或丙泊酚。麻醉药改变了模拟运动的频率、幅度和规律性，对相位滞后影响很小。异氟烷在相似浓度下消除了药理学诱导的与有害刺激诱导的运动输出。丙泊酚通过A型γ-氨基丁酸受体机制消除了药理学诱导的模拟运动。麻醉药对药理学诱发的模拟运动的影响似乎与临床相关，并支持腹角对运动节律产生的制动作用。
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