INSERM-UPMC, UMRS 938, Hôpital Saint-Antoine, 184 rue du Faubourg Saint Antoine, 75012, Paris, France.
Breast Cancer Res Treat. 2011 Nov;130(1):1-10. doi: 10.1007/s10549-011-1689-6. Epub 2011 Aug 5.
Stress enhances glucocorticoid (GC) synthesis, which alters inflammation and immune responses, as well as cellular proliferation and apoptosis in a number of tissues. Increasingly, stress has been associated with cancer progression, and in particular in breast cancer. Consequently, an operational glucocorticoid receptor system in breast tissue influences breast cancer development. In this review, we summarize the data on the GC/GR system in normal and tumoral breast tissue. We also review the molecular mechanisms by which GCs control apoptosis and proliferation in breast cancer models and how GCs alter the chemotherapy of breast cancer treatment when used in combination. Finally, we discuss the participation of GR in breast tumorigenesis under hormone replacement therapy.
压力会增强糖皮质激素（GC）的合成，从而改变许多组织中的炎症和免疫反应，以及细胞增殖和凋亡。越来越多的证据表明，压力与癌症的进展有关，尤其是乳腺癌。因此，乳腺组织中功能性糖皮质激素受体系统会影响乳腺癌的发展。在这篇综述中，我们总结了 GC/GR 系统在正常和肿瘤乳腺组织中的数据。我们还回顾了 GCs 通过何种分子机制控制乳腺癌模型中的细胞凋亡和增殖，以及当与化疗联合使用时 GCs 如何改变乳腺癌治疗的化疗效果。最后，我们讨论了在激素替代疗法下 GR 参与乳腺肿瘤发生的情况。
