Ball N J, Urbanski S J, Green F H, Kieser T
Department of Pathology, University of Calgary, Foothills Hospital, Alberta, Canada.
Am J Surg Pathol. 1990 Apr;14(4):375-8.
We report on the clinical and pathological features of a hitherto unrecognized multicystic and multifocal mesothelial lesion arising in the pleural cavity of a 37-year-old Caucasian woman. The lesions consisted of clusters of thin-walled cysts separated by connective tissue and lined by a single layer of flattened and cuboidal mesothelium. Mucin stains, immunohistochemistry, and electron microscopy were consistent with a mesothelial origin. The pathological features are identical to those of the previously reported multicystic mesotheliomas of the peritoneum. Although these multicystic peritoneal mesothelial lesions have been regarded as neoplasms, absent stromal extension, lack of mitotic activity, and (in this case) continuity with morphologically normal surrounding mesothelium are suggestive of a reactive process. The term "multicystic mesothelial proliferation" may therefore be more appropriate. Because these lesions may be detected as discrete pleural based masses on chest radiograph and CT scan, they may be submitted for frozen section during operative resection. It is therefore important to be aware of their existence, morphology, and differential diagnosis.
我们报告了一名37岁白种女性胸腔内出现的一种此前未被认识的多囊性和多灶性间皮病变的临床和病理特征。病变由薄壁囊肿群组成，囊肿之间由结缔组织分隔，内衬单层扁平立方间皮。黏液染色、免疫组织化学和电子显微镜检查结果均符合间皮起源。其病理特征与先前报道的腹膜多囊性间皮瘤相同。尽管这些多囊性腹膜间皮病变被视为肿瘤，但缺乏间质浸润、无有丝分裂活性以及（在本病例中）与形态正常的周围间皮连续提示为一种反应性过程。因此，“多囊性间皮增生”这一术语可能更为合适。由于这些病变在胸部X线片和CT扫描上可能表现为基于胸膜的离散性肿块，在手术切除时可能会进行冰冻切片检查。因此，了解它们的存在、形态及鉴别诊断很重要。
