Livingston B T, Wilt F H
Department of Molecular and Cell Biology, University of California, Berkeley 94720.
Bioessays. 1990 Mar;12(3):115-9. doi: 10.1002/bies.950120304.
Classical embryological studies have provided a great deal of information on the autonomy and stability of cell fate determination in early sea urchin embryos. However, these studies were limited by the tools available at the time, and the interpretation of the results of these experiments was limited by the lack of information available at the molecular level. Recent studies which have re-examined classical experiments at the molecular level have provided important new insights into the mechanism of determination in sea urchins, and require us to re-evaluate some long standing theories on the process of differentiation.
经典胚胎学研究为早期海胆胚胎中细胞命运决定的自主性和稳定性提供了大量信息。然而，这些研究受到当时可用工具的限制，并且这些实验结果的解释因缺乏分子水平的信息而受到限制。最近在分子水平上重新审视经典实验的研究为海胆的决定机制提供了重要的新见解，并要求我们重新评估一些关于分化过程的长期理论。
