Division of Histology and Neuroanatomy, Department of Anatomy and Physiology, Faculty of Medicine, Saga University, Nabeshima 5-1-1, Saga 849-8501, Japan.
Neurosci Lett. 2011 Sep 20;502(3):157-61. doi: 10.1016/j.neulet.2011.07.032. Epub 2011 Jul 29.
The distribution of oxytocin receptors (OTRs) in the postnatal brain stem of rats was examined by immunohistochemistry. Fibrous or rounded shaped OTR-immunoreactive structures were distributed densely in sensory nuclei, such as the gracile nucleus, the solitary nucleus, and the spinal trigeminal nucleus, evenly in the reticular formation of the medulla oblongata and pons, and moderately in the locus coeruleus during the neonatal period, but disappeared by postnatal day 10. Few OTR-immunoreactive structures were distributed in motor nuclei. Many rounded OTR-immunoreactive structures were discovered layered and partially overlapping with GM-130-immunoreacivity in the neuronal Golgi apparatus, which was confirmed by electron microscopy. The present study suggests that a transient type of OTR may be functioning in neuronal development during the neonatal period.
通过免疫组织化学方法研究了大鼠出生后脑干中催产素受体（OTR）的分布。纤维状或圆形的 OTR 免疫反应结构在感觉核（如薄束核、孤束核和三叉神经脊束核）中密集分布，在延髓和脑桥的网状结构中均匀分布，在蓝斑核中中度分布在新生儿期，但在出生后第 10 天消失。运动核中分布的 OTR 免疫反应结构很少。许多圆形的 OTR 免疫反应结构被发现与神经元高尔基器中的 GM-130 免疫反应性分层且部分重叠，这一点通过电子显微镜得到了证实。本研究表明，一种短暂的 OTR 可能在新生儿期的神经元发育中发挥作用。
