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醌型和吩嗪类化合物：对 H37Rv、利福平及异烟肼耐药结核分枝杆菌的合成与评价。

Quinonoid and phenazine compounds: synthesis and evaluation against H37Rv, rifampicin and isoniazid-resistance strains of Mycobacterium tuberculosis.

机构信息

Núcleo de Pesquisas de Produtos Naturais, UFRJ, 21941-971 Rio de Janeiro, Brazil.

出版信息

Eur J Med Chem. 2011 Sep;46(9):4521-9. doi: 10.1016/j.ejmech.2011.07.026. Epub 2011 Jul 23.

DOI:10.1016/j.ejmech.2011.07.026
PMID:21820768
Abstract

Several quinonoid and phenazine compounds were synthesized in moderate to high yields and showed activity against H(37)Rv, rifampicin and isoniazid-resistance strains of Mycobacterium tuberculosis. The cytotoxity of the compounds were evaluated against human peripheral blood mononuclear cells (PBMC) and these substances emerge as promising antitubercular prototypes.

摘要

几种醌型和吩嗪类化合物以中等至高产率合成，并显示出对 H(37)Rv、利福平以及异烟肼耐药结核分枝杆菌菌株的活性。这些化合物的细胞毒性针对人外周血单核细胞 (PBMC) 进行了评估，这些物质作为有前途的抗结核原型出现。

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