Banner Alzheimer's Institute, Phoenix, AZ 85006, USA.
Neurobiol Aging. 2012 Apr;33(4):827.e11-9. doi: 10.1016/j.neurobiolaging.2011.06.020. Epub 2011 Aug 6.
Epidemiological studies suggest that elevated blood pressure (BP) in midlife is associated with increased risk of Alzheimer's disease (AD) in late life. In this preliminary study, we investigated the extent to which BP measurements are related to positron emission tomography (PET) measurements of fibrillar amyloid-beta burden using Pittsburgh Compound-B (PiB) and fluorodeoxyglucose (FDG) PET measures of cerebral metabolic rate for glucose metabolism (CMRgl) in cognitively normal, late middle-aged to older adult apolipoprotein E (APOE) ε4 homozygotes, heterozygotes and noncarriers. PiB PET results revealed that systolic BP (SBP) and pulse pressure (PP) were each positively correlated with cerebral-to-cerebellar PiB distribution volume ratio (DVR) in frontal, temporal, and posterior-cingulate/precuneus regions, whereas no significant positive correlations were found between PiB distribution volume ratios and diastolic BP (DBP). FDG PET results revealed significant inverse correlations between each of the BP measures and lower glucose metabolism in frontal and temporal brain regions. These preliminary findings provide additional evidence that higher BP, likely a reflection of arterial stiffness, during late midlife may be associated with increased risk of presymptomatic AD.
流行病学研究表明，中年时期血压升高与晚年阿尔茨海默病（AD）风险增加有关。在这项初步研究中，我们调查了血压测量与正电子发射断层扫描（PET）测量的淀粉样蛋白-β纤维负担之间的关系，使用匹兹堡化合物-B（PiB）和氟脱氧葡萄糖（FDG）PET 测量脑葡萄糖代谢的脑代谢率（CMRgl）在认知正常的中老年至老年载脂蛋白 E（APOE）ε4 纯合子、杂合子和非携带者中。PiB PET 结果显示，收缩压（SBP）和脉压（PP）均与额叶、颞叶和后扣带回/楔前叶区域的脑-小脑 PiB 分布容积比（DVR）呈正相关，而 PiB 分布容积比与舒张压（DBP）之间无显著正相关。FDG PET 结果显示，血压测量值与额叶和颞叶脑区的葡萄糖代谢率降低呈显著负相关。这些初步发现提供了更多证据表明，中年后期血压升高（可能反映了动脉僵硬）可能与无症状 AD 的发生风险增加有关。
