Department of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Ultrasound Med Biol. 2011 Oct;37(10):1635-43. doi: 10.1016/j.ultrasmedbio.2011.06.014. Epub 2011 Aug 6.
This study investigated the effects of ultrasound (US) at different frequencies on fracture healing over a three-week period in a rabbit fibular fracture model. Forty-five adult New Zealand White rabbits were divided into five groups: a control group and four groups treated with US frequencies of 0.5, 1.0, 1.5 and 2.0 MHz (0.5 W/cm(2), 200-μs burst, pulsed 1:4). After anesthesia, transverse osteotomy was performed on the fibula bone. This was followed by intravital staining and fluorescence microscopic examination of new bone formation and biomechanical tests of torsional stiffness at the osteotomy site. Results showed that total new bone formation and torsional stiffness of the fibula were greater in all US-treated groups than in the control group. No significant difference was found between any of the four US-treated groups. The US treatment also enhanced bone growth of the sham-treated contralateral fracture site. These results suggest that US treatment at 0.5, 1.0, 1.5 or 2.0 MHz can enhance fracture healing in a rabbit model. Furthermore, the effects of US on fracture healing at present parameters might not be confined locally.
本研究旨在探讨在兔腓骨骨折模型中，不同频率的超声（US）对骨折愈合的影响，为期 3 周。将 45 只成年新西兰白兔随机分为 5 组：对照组和 4 个 US 频率组（0.5、1.0、1.5 和 2.0 MHz，0.5 W/cm²，200-μs 脉冲，1:4）。麻醉后，对腓骨进行横断骨折。然后对新骨形成进行活体染色和荧光显微镜检查，并对骨折部位的扭转刚度进行生物力学测试。结果显示，所有 US 治疗组的总新骨形成和腓骨扭转刚度均大于对照组。四个 US 治疗组之间无显著差异。US 治疗还增强了假手术对侧骨折部位的骨生长。这些结果表明，0.5、1.0、1.5 或 2.0 MHz 的 US 治疗可增强兔模型中的骨折愈合。此外，目前参数下 US 对骨折愈合的影响可能不仅局限于局部。
