Goodfield M J, Hume A, Rowell N R
Department of Dermatology, General Infirmary, Leeds.
Br J Rheumatol. 1990 Apr;29(2):89-91. doi: 10.1093/rheumatology/29.2.89.
The acute effects of smoking a single cigarette on peripheral blood flow were investigated by laser-Doppler flowmetry in nine patients with Raynaud's phenomenon and 12 normal controls. In regular smokers, a marked fall in finger blood flow was demonstrated, but this was not present in non- or irregular smokers. In addition, no effect on capillary blood flow was found. There was no difference between subjects with and without Raynaud's phenomenon. In five normal, non-smoking volunteers, 2.4 g of aspirin for 3 days resulted in a similar fall in blood flow due to a single cigarette. These results suggest that regular smoking sensitizes the peripheral vasculature to the vasoconstricting effects of the next cigarette, and that at least part of this sensitization is mediated by the inhibition of endothelial prostacyclin synthesis. Patients with Raynaud's phenomenon, either primary or secondary, are no more sensitive than normal subjects, but should nevertheless avoid cigarette smoking.
通过激光多普勒血流仪对9例雷诺现象患者和12名正常对照者进行研究，以探讨吸一支烟对外周血流的急性影响。在经常吸烟者中，手指血流明显下降，但在不吸烟者或偶尔吸烟者中未出现这种情况。此外，未发现对毛细血管血流有影响。有雷诺现象和无雷诺现象的受试者之间没有差异。在5名正常不吸烟志愿者中，服用2.4克阿司匹林3天导致吸一支烟后血流出现类似下降。这些结果表明，经常吸烟会使外周血管系统对下一支烟的血管收缩作用敏感，并且这种敏感性至少部分是由内皮前列环素合成受抑制介导的。原发性或继发性雷诺现象患者并不比正常受试者更敏感，但仍应避免吸烟。
