Carroll Christopher L, Chamberlin A Richard
Department of Chemistry, University of California, Irvine, Irvine, California 92697, USA.
Tetrahedron Lett. 2011 Aug 3;52(31):3995-3997. doi: 10.1016/j.tetlet.2011.05.106.
A concise stereoselective route to the dysiherbaine tetrahydropyran core was achieved in 9 steps and 39% overall yield. Donohoe's improved tethered aminohydroxylation conditions were employed to concurrently install the amino and alcohol groups and construct the tetrahydropyran ring, which features four contiguous cis-stereocenters.
通过9步反应，以39%的总收率实现了一条简洁的立体选择性合成dysiherbaine四氢吡喃核心结构的路线。采用了多诺霍改进的 tethered 氨基羟基化条件，同时引入氨基和醇基并构建四氢吡喃环，该环具有四个相邻的顺式立体中心。
