Sherry S
Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19140.
Clin Cardiol. 1990 Mar;Suppl 5:V3-10; discussion V27-32. doi: 10.1002/clc.4960131303.
Eminase (anistreplase), or anisoylated plasminogen streptokinase activator complex (APSAC), is a reversibly inactivated lys-plasminogen-streptokinase activator complex that is given rapidly over a period of 2-5 minutes, and has a half-life in the circulation of 90-105 min. Eminase represents a significant advance in drug design for therapeutic thrombolysis based on convenience in administration, high gradient (especially initially) for diffusion into thrombus, improved fibrin binding, ability to lyse fibrin rapidly, improved stability in the circulation, long duration of action, and production of an antithrombotic state.
埃米那酶（茴香酰化纤溶酶原链激酶激活剂复合物，APSAC）是一种可逆性失活的赖氨酸纤溶酶原-链激酶激活剂复合物，在2至5分钟内快速给药，在循环中的半衰期为90至105分钟。基于给药方便、向血栓内扩散的高梯度（尤其是最初）、改善的纤维蛋白结合、快速溶解纤维蛋白的能力、在循环中更好的稳定性、作用持续时间长以及产生抗血栓状态，埃米那酶在治疗性溶栓的药物设计方面取得了重大进展。
