The Fourth People's Hospital of Jinan, The Second Affiliated Hospital of Tai Shan Medical College, Jinan, China.
Cell Biochem Biophys. 2012 Jan;62(1):83-6. doi: 10.1007/s12013-011-9262-9.
The changes of left ventricular ejection fraction (LVEF) were assessed after successful recanalization of chronic total occlusions (CTO) with or without previous myocardial infarction (MI) by real-time three-dimensional echocardiography (RT3DE). 32 patients with a successfully recanalyzed CTO were included in the present prospective study. The patients were divided into group 1 without previous MI and group 2 with previous MI in the territories of total occlusion vessel that was recanalized. In addition, there was a subgroup composed of 14 patients with collateral flow or retrograde flow in group 2. In all patients, LVEF was determined by RT3DE at baseline and after 6 weeks. In group 1, the evolution of LVEF increased significantly from 59.9 ± 7.2-67.5 ± 8.7% (P < 0.05). In group 2, the evolution of LVEF increased from 48.6 ± 6.1-50.1 ± 6.4%, however, it was without statistic significance (P > 0.05). The evolution of LVEF increased from 46.8 ± 7.1-53.0 ± 7.2% (P < 0.05) in the subgroup of group 2. Left ventricular function in patients with CTO can be feasibility and actually evaluated by RT3DE. The influence of recanalization of CTO on the improvement of left ventricular function was different between MI and non-MI patients. The left ventricular function did not improve in MI patients, but improved significantly in the patients having rich collateral circulation.
通过实时三维超声心动图（RT3DE）评估成功再通慢性完全闭塞（CTO）后左心室射血分数（LVEF）的变化，无论是否有先前的心肌梗死（MI）。本前瞻性研究纳入了 32 例成功再通 CTO 的患者。患者分为无先前 MI 的组 1 和闭塞血管完全再通前有先前 MI 的组 2。此外，在组 2 中，有 14 例患者存在侧支循环或逆行血流，组成亚组。所有患者均在基线和 6 周时通过 RT3DE 测定 LVEF。在组 1 中，LVEF 从 59.9±7.2%增加至 67.5±8.7%（P<0.05），呈显著增加。在组 2 中，LVEF 从 48.6±6.1%增加至 50.1±6.4%，但无统计学意义（P>0.05）。组 2 亚组的 LVEF 从 46.8±7.1%增加至 53.0±7.2%（P<0.05）。RT3DE 可对 CTO 患者的左心室功能进行可行性和实际评估。CTO 再通对左心室功能改善的影响在 MI 和非 MI 患者之间存在差异。MI 患者的左心室功能没有改善，但有丰富侧支循环的患者显著改善。
