1st Department of Obstetrics and Gynecology, Alexandra Hospital, Athens University Medical School, G! Septembriou Street, 10433, Athens, Greece.
Arch Gynecol Obstet. 2012 Jan;285(1):265-70. doi: 10.1007/s00404-011-2019-2. Epub 2011 Aug 7.
To compare endometrial and subendometrial morphological changes and vascularity as measured by 3D Power Doppler sonography, based on a specific scoring system between women subjected or not to oxytocine receptor antagonist (OTRa) during IVF cycles.
Twenty-six women were divided into groups according to OTRa (Atosiban tractocide) administration. The first group (control n = 13 women) was examined with 3D Power Doppler 3 days after embryo transfer. The second group (n = 13 women) was administered 7.5 mg intravenous tractocide 2 days after embryo transfer and a 3D Power Doppler was performed after a day.
The control group presented the following ultrasonographic characteristics: (a) echogenic endometrium in all cases, (b) endometrial thickness >7 mm in all cases (84.6%), (c) endometrial volume >2.31 cm(3) in 5 cases (38.5%), (d) abnormal sub-endometrial halo in 3 cases (23.1%), (e) endometrial blood flow in 6 cases (46.2%) and (f) complex vessel's architecture in 2 cases (15.4%). In women who underwent OTRa administration were observed: (a) echogenic endometrium in 1 case (7.7%), triple line endometrium in 12 cases (92.3%), (b) endometrial thickness >7 mm in all cases, (c) endometrial volume >2.31 cm(3) in 11 cases (84.6%), (d) abnormal sub-endometrial halo in 3 cases (23.1%), (e) endometrial blood flow in 11 cases (84.6%) and (f) complex vessel's architecture in 6 cases (46.2%).
Women who have taken OTRa presented an endometrium with characteristics more predictive of implantation.
比较经体外受精（IVF）周期使用催产素受体拮抗剂（OTRa）与未使用 OTra 妇女的子宫内膜和内膜下形态变化及血管变化，并基于特定评分系统进行评估。
根据 OTra（阿托西班）的使用情况将 26 名妇女分为两组。第一组（对照组 n=13 名妇女）在胚胎移植后 3 天进行 3D 能量多普勒超声检查。第二组（n=13 名妇女）在胚胎移植后 2 天静脉注射 7.5mg 阿托西班，并在 1 天后进行 3D 能量多普勒超声检查。
对照组呈现出以下超声特征：（a）所有病例均为回声增强的子宫内膜；（b）所有病例的子宫内膜厚度>7mm（84.6%）；（c）5 例（38.5%）的子宫内膜体积>2.31cm³；（d）3 例（23.1%）出现异常的内膜下晕；（e）6 例（46.2%）存在子宫内膜血流；（f）2 例（15.4%）存在复杂的血管结构。接受 OTra 治疗的妇女观察到：（a）1 例（7.7%）出现回声增强的子宫内膜，12 例（92.3%）出现三线状子宫内膜；（b）所有病例的子宫内膜厚度>7mm；（c）11 例（84.6%）的子宫内膜体积>2.31cm³；（d）3 例（23.1%）出现异常的内膜下晕；（e）11 例（84.6%）存在子宫内膜血流；（f）6 例（46.2%）存在复杂的血管结构。
使用 OTra 的妇女的子宫内膜具有更高的着床预测特征。
