在 IVF 项目中使用催产素受体拮抗剂（OTRa）后对人子宫内膜的三维能量多普勒评估。
Three Dimensional Power Doppler evaluation of human endometrium after administration of oxytocine receptor antagonist (OTRa) in an IVF program.
机构信息
1st Department of Obstetrics and Gynecology, Alexandra Hospital, Athens University Medical School, G! Septembriou Street, 10433, Athens, Greece.
出版信息
Arch Gynecol Obstet. 2012 Jan;285(1):265-70. doi: 10.1007/s00404-011-2019-2. Epub 2011 Aug 7.
PURPOSE
To compare endometrial and subendometrial morphological changes and vascularity as measured by 3D Power Doppler sonography, based on a specific scoring system between women subjected or not to oxytocine receptor antagonist (OTRa) during IVF cycles.
METHODS
Twenty-six women were divided into groups according to OTRa (Atosiban tractocide) administration. The first group (control n = 13 women) was examined with 3D Power Doppler 3 days after embryo transfer. The second group (n = 13 women) was administered 7.5 mg intravenous tractocide 2 days after embryo transfer and a 3D Power Doppler was performed after a day.
RESULTS
The control group presented the following ultrasonographic characteristics: (a) echogenic endometrium in all cases, (b) endometrial thickness >7 mm in all cases (84.6%), (c) endometrial volume >2.31 cm(3) in 5 cases (38.5%), (d) abnormal sub-endometrial halo in 3 cases (23.1%), (e) endometrial blood flow in 6 cases (46.2%) and (f) complex vessel's architecture in 2 cases (15.4%). In women who underwent OTRa administration were observed: (a) echogenic endometrium in 1 case (7.7%), triple line endometrium in 12 cases (92.3%), (b) endometrial thickness >7 mm in all cases, (c) endometrial volume >2.31 cm(3) in 11 cases (84.6%), (d) abnormal sub-endometrial halo in 3 cases (23.1%), (e) endometrial blood flow in 11 cases (84.6%) and (f) complex vessel's architecture in 6 cases (46.2%).
CONCLUSIONS
Women who have taken OTRa presented an endometrium with characteristics more predictive of implantation.
目的
比较经体外受精（IVF）周期使用催产素受体拮抗剂（OTRa）与未使用 OTra 妇女的子宫内膜和内膜下形态变化及血管变化，并基于特定评分系统进行评估。
方法
根据 OTra（阿托西班）的使用情况将 26 名妇女分为两组。第一组（对照组 n=13 名妇女）在胚胎移植后 3 天进行 3D 能量多普勒超声检查。第二组（n=13 名妇女）在胚胎移植后 2 天静脉注射 7.5mg 阿托西班，并在 1 天后进行 3D 能量多普勒超声检查。
结果
对照组呈现出以下超声特征：（a）所有病例均为回声增强的子宫内膜；（b）所有病例的子宫内膜厚度>7mm（84.6%）；（c）5 例（38.5%）的子宫内膜体积>2.31cm³；（d）3 例（23.1%）出现异常的内膜下晕；（e）6 例（46.2%）存在子宫内膜血流；（f）2 例（15.4%）存在复杂的血管结构。接受 OTra 治疗的妇女观察到：（a）1 例（7.7%）出现回声增强的子宫内膜，12 例（92.3%）出现三线状子宫内膜；（b）所有病例的子宫内膜厚度>7mm；（c）11 例（84.6%）的子宫内膜体积>2.31cm³；（d）3 例（23.1%）出现异常的内膜下晕；（e）11 例（84.6%）存在子宫内膜血流；（f）6 例（46.2%）存在复杂的血管结构。
结论
使用 OTra 的妇女的子宫内膜具有更高的着床预测特征。
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