Zhonghua Fu Chan Ke Za Zhi. 1990 Jan;25(1):31-4, 62.
Abortion was attempted in 316 healthy women in early pregnancy within 7 weeks with the RU486 alone (600mg in a single oral dose) or in combination with a PG (15-dl-methyl-PGF2 alpha-methyl-ester) 1 mg suppository. The result of using RU 486 alone in 204 women was complete abortion 65.2%, incomplete 3.4% and continued pregnancy 31.4%. While RU486 and PG in 112 women resulted in complete abortion 87.5%, incomplete 8.9% and continued pregnancy 3.6%. The complete abortion rate of RU486 and PG was significantly higher than that of the RU486 alone (P less than 0.01). In RU486 and PG group, the measured mean blood loss after complete abortion (52.0 ml) was much less than in the RU486 alone (177.4ml). The main side-effects were nausea vomiting and headache. The RU486 and PG is an effective and safe agent for termination of early pregnancy. However, it should be used only under close medical supervision.
对316名妊娠7周内的健康早孕妇女尝试进行流产，单独使用米非司酮（单次口服剂量600毫克）或与前列腺素（15 - 去甲 - 甲基 - PGF2α - 甲酯）1毫克栓剂联合使用。204名妇女单独使用米非司酮的结果是完全流产65.2%，不完全流产3.4%，继续妊娠31.4%。而112名妇女使用米非司酮和前列腺素后完全流产率为87.5%，不完全流产8.9%，继续妊娠3.6%。米非司酮和前列腺素的完全流产率显著高于单独使用米非司酮（P＜0.01）。在米非司酮和前列腺素组，完全流产后测得的平均失血量（52.0毫升）远少于单独使用米非司酮组（177.4毫升）。主要副作用为恶心、呕吐和头痛。米非司酮和前列腺素是终止早孕的一种有效且安全的药物。然而，它应仅在密切的医疗监督下使用。
