钕钇铝石榴石激光、热探头与不进行内镜治疗对消化性溃疡出血的随机对照比较。

Randomized comparison of Nd YAG laser, heater probe, and no endoscopic therapy for bleeding peptic ulcers.

作者信息

Matthewson K, Swain C P, Bland M, Kirkham J S, Bown S G, Northfield T C

机构信息

Norman Tanner Gastroenterology Unit, St. James' Hospital, London, England.

出版信息

Gastroenterology. 1990 May;98(5 Pt 1):1239-44. doi: 10.1016/0016-5085(90)90339-3.

DOI:10.1016/0016-5085(90)90339-3

PMID:2182370

Abstract

Of 550 patients admitted with acute upper gastrointestinal hemorrhage, 143 with peptic ulcers containing stigmata of recent hemorrhage accessible to endoscopic therapy were included in a randomized comparison of neodymium yttrium aluminum garnet laser, heater probe, and no endoscopic therapy. The rebleeding rate in laser-treated patients (20%) was significantly less than in controls (42%; p less than 0.05), but in heater probe-treated patients (28%) it was not significantly different from either of the other two groups. The mortality rate in the laser group (2%) was not significantly different from either the heater probe (10%) or the control (9%) group. This trial has confirmed the efficacy of the Nd YAG laser but not that of the heater probe in the prevention of rebleeding from recently bleeding peptic ulcers.

摘要

在550例因急性上消化道出血入院的患者中，143例患有近期出血迹象且可通过内镜治疗的消化性溃疡患者被纳入钕钇铝石榴石激光、热探头及非内镜治疗的随机对照研究。激光治疗组患者的再出血率（20%）显著低于对照组（42%；P<0.05），但热探头治疗组患者的再出血率（28%）与其他两组相比无显著差异。激光组的死亡率（2%）与热探头组（10%）或对照组（9%）相比无显著差异。该试验证实了钕钇铝石榴石激光在预防近期出血性消化性溃疡再出血方面的疗效，但未证实热探头的疗效。