Kupfer D J, Coble P, Kane J, Petti T, Conners C K
Psychopharmacology (Berl). 1979 Jan 31;60(2):117-23. doi: 10.1007/BF00432281.
Depression in children is currently an area of considerable controversy, as is the use of potent psychopharmacologic agents in children. Since EEG sleep techniques have proven to be useful in understanding the mechanisms of depression in adults and in predicting their response to antidepressants, a pilot study employing these techniques was undertaken in a population of hospitalized children. The EEG sleep of 12 children with significant depressive symptomatology was first examined after a two-week drug-free period and again approximately three weeks later when an optimum dose of imipramine had been maintained for at least 7 -- 10 days. Changes in sleep continuity, as reflected in increased wakefulness and a decreased sleep efficiency, as well as an increase in Stage 2 and a decrease in Stage 4 sleep, were observed throughout the entire sample. REM suppression was also noted, but tended to be most pronounced in those children who improved on imipramine.
儿童抑郁症目前是一个存在相当大争议的领域，儿童使用强效精神药物的情况也是如此。由于脑电图睡眠技术已被证明有助于理解成人抑郁症的机制并预测他们对抗抑郁药的反应，因此在一群住院儿童中开展了一项采用这些技术的试点研究。在为期两周的无药期后，首先对12名有明显抑郁症状的儿童进行脑电图睡眠检查，大约三周后，当丙咪嗪的最佳剂量已维持至少7至10天时，再次进行检查。在整个样本中观察到睡眠连续性的变化，表现为清醒时间增加和睡眠效率降低，以及第二阶段睡眠增加和第四阶段睡眠减少。还注意到快速眼动睡眠受到抑制，但在服用丙咪嗪后病情改善的儿童中往往最为明显。
