Imkamp E, Mittermayer C, Hunold W
Abteilung Pathologie, Zellkulturlabor, Neues Klinikum, Aachen.
Fortschr Ophthalmol. 1990;87(1):95-8.
In spite of the great clinical success of cataract surgery and intraocular lens implantation, adverse reactions still occur. In 2-3% of all cases, there is acute or chronic inflammation. One reason might be that the biocompatibility of the lens material is insufficient. This study evaluates the biocompatibility of dyed and undyed transparent PMMA lens haptics. The haptics were implanted subcutaneously in mobile and immobile mice tissue. After different implantation periods varying from 1 week to 6 months, the haptics were removed and evaluated histologically. The undyed PMMA lens haptics showed no adverse reactions. The dyed PMMA lens haptics showed a strong inflammatory response caused by diffusion of the dye into the surrounding tissue.
尽管白内障手术和人工晶状体植入术在临床上取得了巨大成功，但不良反应仍会发生。在所有病例中，有2%-3%会出现急性或慢性炎症。一个原因可能是晶状体材料的生物相容性不足。本研究评估了染色和未染色的透明聚甲基丙烯酸甲酯（PMMA）晶状体襻的生物相容性。将襻皮下植入活动和不活动的小鼠组织中。在1周至6个月的不同植入期后，取出襻并进行组织学评估。未染色的PMMA晶状体襻未显示不良反应。染色的PMMA晶状体襻因染料扩散到周围组织而显示出强烈的炎症反应。
