Takahashi Hironori, Takahashi Shigehiro, Tsukamoto Keiko, Ito Yushi, Nakamura Tomoo, Hayashi Satoshi, Sago Haruhiko
Department of Maternal-Fetal and Neonatal Medicine, National Center for Child Health and Development, Tokyo, Japan.
J Matern Fetal Neonatal Med. 2012 May;25(5):543-5. doi: 10.3109/14767058.2011.594469. Epub 2011 Aug 10.
We investigated persistent pulmonary hypertension of the newborn (PPHN) among monochorionic-diamniotic (MD) twins.
A retrospective cohort study examined MD twins from 195 deliveries and 373 live-born neonates at our center.
PPHN occurred in three cases (3/373: 0.8%), all of which were recipients of twin-twin transfusion syndrome (TTTS), after fetoscopic laser surgery (FLS) (3/117: 2.6%). Although the clinical course of the three cases differed, all cardiothoracic area ratios exceeded 40%, and other cardiac parameters also worsened after FLS.
The occurrence of PPHN in TTTS recipients should be noted, particularly when fetal cardiac function declines following FLS.
我们调查了单绒毛膜双羊膜囊（MD）双胎中的新生儿持续性肺动脉高压（PPHN）情况。
一项回顾性队列研究对本中心195例分娩的MD双胎及373例活产新生儿进行了检查。
PPHN发生于3例（3/373：0.8%），所有病例均为双胎输血综合征（TTTS）受血儿，且均在胎儿镜激光手术（FLS）后发生（3/117：2.6%）。尽管这3例的临床过程有所不同，但所有心胸面积比均超过40%，且FLS后其他心脏参数也恶化。
应注意TTTS受血儿中PPHN的发生，尤其是在FLS后胎儿心功能下降时。
