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[1例局部晚期非小细胞肺癌经诱导化疗后行主动脉弓切除术后长期生存的病例]

[A case of long-term survival after resection of aortic arch for locally advanced non-small cell lung cancer with induction chemotherapy].

作者信息

Higuchi Mitsunori, Suzuki Hiroyuki, Shio Yutaka, Satoh Yoichi, Kitamura Masatoshi, Gotoh Mitsukazu

机构信息

Dept. of Regenerative Surgery, Fukushima Medical University School of Medicine.

出版信息

Gan To Kagaku Ryoho. 2011 Aug;38(8):1349-52.

PMID:21829079
Abstract

Our patient was a 57-year-old male with a history of esophageal cancer. He was referred to our hospital for squamous cell lung carcinoma(SCC). Chest computed tomography identified a mass in the left lung field, which was suspected to be invading the reconstructed gastric tube, left subclavian artery, common carotid artery, and distal aortic arch. He was diagnosed as primary pulmonary squamous cell carcinoma(SCC)because six years had already passed since a previous surgery for early esophageal cancer. He received three courses of induction chemotherapy including S-1/CDDP. We evaluated the therapy as a partial response. He underwent an extended resection of distal aortic arch and left subclavian artery with left upper lobectomy, and those vessels were reconstructed using prosthetic grafts. Pathological findings showed the tumor as a well differentiated SCC of pT4N0M0 at stage III A, with a residual tumor on the reconstructed gastric tube, even though the effect of induction chemotherapy was Ef2. He received three courses of S-1/CDDP after surgery. The patient has been well without recurrence for 31 months after surgery.

摘要

我们的患者是一名57岁男性,有食管癌病史。他因肺鳞状细胞癌(SCC)被转诊至我院。胸部计算机断层扫描发现左肺野有一个肿块,怀疑侵犯了重建的胃管、左锁骨下动脉、颈总动脉和主动脉弓远端。由于距离先前早期食管癌手术已过去六年,他被诊断为原发性肺鳞状细胞癌(SCC)。他接受了包括S-1/顺铂在内的三个疗程诱导化疗。我们评估该治疗为部分缓解。他接受了主动脉弓远端和左锁骨下动脉的扩大切除术及左上叶切除术,并用人工血管移植重建了这些血管。病理结果显示肿瘤为III A期高分化SCC,pT4N0M0,尽管诱导化疗效果为Ef2,但重建胃管上仍有残留肿瘤。术后他接受了三个疗程的S-1/顺铂治疗。患者术后31个月情况良好,无复发。

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Gan To Kagaku Ryoho. 2011 Aug;38(8):1349-52.
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