Department of Urology, St Bartholomew's hospital, Barts and The London NHS Trust, West Smithfield, London EC1A 7BE, UK.
Br J Cancer. 2011 Aug 9;105(4):481-5. doi: 10.1038/bjc.2011.273.
It is recognised that the risk of prostate cancer is higher in black men than in white men worldwide. Recent studies suggest that a number of genetic mutations in black men predispose them to this disease; hence, race as well as environmental factors such as diet and migration are thought to be the determining factors.
This review compares data from the United States (US), which suggest that African-American men have a 60% higher risk for developing prostate cancer with poorer prognosis in comparison with their white counterparts, with similar studies carried out in the United Kingdom (UK) and also in African and Caribbean countries.
Studies from the United States and the United Kingdom came to significantly different conclusions, and this has implications for policy development, awareness raising among black men in each country and clinical practice.
在全球范围内，黑人男性患前列腺癌的风险高于白人男性，这一点已得到公认。最近的研究表明，黑人男性存在一些遗传基因突变，使他们更容易患上这种疾病；因此，种族以及饮食和移民等环境因素被认为是决定性因素。
本综述比较了来自美国的数据，这些数据表明，与白种人相比，非裔美国男性患前列腺癌的风险高出 60%，且预后较差，而在英国和非洲及加勒比国家也进行了类似的研究。
来自美国和英国的研究得出了截然不同的结论，这对政策制定、两国黑人男性的意识提高以及临床实践都有影响。
