前列腺癌的种族差异。
Ethnic differences in prostate cancer.
机构信息
Department of Urology, St Bartholomew's hospital, Barts and The London NHS Trust, West Smithfield, London EC1A 7BE, UK.
出版信息
Br J Cancer. 2011 Aug 9;105(4):481-5. doi: 10.1038/bjc.2011.273.
Abstract
BACKGROUND
It is recognised that the risk of prostate cancer is higher in black men than in white men worldwide. Recent studies suggest that a number of genetic mutations in black men predispose them to this disease; hence, race as well as environmental factors such as diet and migration are thought to be the determining factors.
METHODS
This review compares data from the United States (US), which suggest that African-American men have a 60% higher risk for developing prostate cancer with poorer prognosis in comparison with their white counterparts, with similar studies carried out in the United Kingdom (UK) and also in African and Caribbean countries.
CONCLUSIONS
Studies from the United States and the United Kingdom came to significantly different conclusions, and this has implications for policy development, awareness raising among black men in each country and clinical practice.
摘要
背景
在全球范围内，黑人男性患前列腺癌的风险高于白人男性，这一点已得到公认。最近的研究表明，黑人男性存在一些遗传基因突变，使他们更容易患上这种疾病；因此，种族以及饮食和移民等环境因素被认为是决定性因素。
方法
本综述比较了来自美国的数据，这些数据表明，与白种人相比，非裔美国男性患前列腺癌的风险高出 60%，且预后较差，而在英国和非洲及加勒比国家也进行了类似的研究。
结论
来自美国和英国的研究得出了截然不同的结论，这对政策制定、两国黑人男性的意识提高以及临床实践都有影响。
相似文献
1
Ethnic differences in prostate cancer.前列腺癌的种族差异。
Br J Cancer. 2011 Aug 9;105(4):481-5. doi: 10.1038/bjc.2011.273.
2
Why do African-American men suffer more prostate cancer?为什么非裔美国男性患前列腺癌的情况更为严重？
J Natl Cancer Inst. 1997 Feb 5;89(3):188-9. doi: 10.1093/jnci/89.3.188.
3
Prostate cancer in black men of African-Caribbean descent.非洲加勒比裔黑人男性中的前列腺癌。
J Cult Divers. 2003 Summer;10(2):56-61.
4
Prostate cancer among Jamaican men: exploring the evidence for higher risk.牙买加男性中的前列腺癌：探究高风险证据。
Br J Nurs. 2016 Oct 27;25(19):1046-1051. doi: 10.12968/bjon.2016.25.19.1046.
5
The risk of prostate cancer amongst black men in the United Kingdom: the PROCESS cohort study.英国黑人男性患前列腺癌的风险：PROCESS队列研究。
Eur Urol. 2008 Jan;53(1):99-105. doi: 10.1016/j.eururo.2007.02.047. Epub 2007 Mar 1.
6
Prostate cancer in black and white Americans.美国黑人和白人中的前列腺癌。
Cancer Metastasis Rev. 2003 Mar;22(1):83-6. doi: 10.1023/a:1022216119066.
7
Re: prostate cancer in relation to diet, physical activity, and body size in blacks, whites, and Asians in the United States and Canada.
J Natl Cancer Inst. 1995 Sep 6;87(17):1329-31. doi: 10.1093/jnci/87.17.1329.
8
Dietary factors and risks for prostate cancer among blacks and whites in the United States.美国黑人和白人的饮食因素与前列腺癌风险
Cancer Epidemiol Biomarkers Prev. 1999 Jan;8(1):25-34.
9
Association of African-American ethnic background with survival in men with metastatic prostate cancer.非裔美国人种族背景与转移性前列腺癌男性患者生存情况的关联
J Natl Cancer Inst. 2001 Feb 7;93(3):219-25. doi: 10.1093/jnci/93.3.219.
10
Racial variation in prostate cancer incidence and in hormonal system markers among male health professionals.男性健康专业人员中前列腺癌发病率及激素系统标志物的种族差异。
J Natl Cancer Inst. 2000 Dec 20;92(24):2009-17. doi: 10.1093/jnci/92.24.2009.
引用本文的文献
1
Predicting Bone Metastasis in Prostate Cancer Patients Using Total Serum Prostate-Specific Antigen and Serum Alkaline Phosphatase: Model Development, Validation, and Deployment as a Digital Risk Estimator.利用总血清前列腺特异性抗原和血清碱性磷酸酶预测前列腺癌患者的骨转移：模型开发、验证及作为数字风险评估工具的应用
Cureus. 2025 Jul 12;17(7):e87786. doi: 10.7759/cureus.87786. eCollection 2025 Jul.
2
Role of Rs228648 and Rs2890565 single nucleotide polymorphisms in Urotensin-2 gene in prostate cancer.Urotensin-2基因中Rs228648和Rs2890565单核苷酸多态性在前列腺癌中的作用
Mol Biol Rep. 2025 Jun 9;52(1):572. doi: 10.1007/s11033-025-10662-5.
3
Disparities Between Rural and Urban Patients With Prostate Cancer in Nebraska.内布拉斯加州前列腺癌城乡患者之间的差异
Cancer Med. 2025 Mar;14(6):e70812. doi: 10.1002/cam4.70812.
4
Clinicopathological correlates of vitamin D receptor expression in prostate cancer: results of genomic analysis.前列腺癌中维生素D受体表达的临床病理相关性：基因组分析结果
Porto Biomed J. 2025 Feb 17;10(1):e280. doi: 10.1097/j.pbj.0000000000000280. eCollection 2025 Jan-Feb.
5
Racial disparities in prostate cancer in the UK and the USA: similarities, differences and steps forwards.英国和美国前列腺癌的种族差异：异同及未来进展
Nat Rev Urol. 2025 Apr;22(4):223-234. doi: 10.1038/s41585-024-00948-x. Epub 2024 Oct 18.
6
Prognostic significance of soluble PD-L1 in prostate cancer.可溶性 PD-L1 在前列腺癌中的预后意义。
Front Immunol. 2024 Jul 11;15:1401097. doi: 10.3389/fimmu.2024.1401097. eCollection 2024.
7
Quality of life assessment among ethnically diverse Black prostate cancer survivors: a constructivist grounded theory approach.不同种族黑人前列腺癌幸存者的生活质量评估：一种建构主义扎根理论方法。
J Cancer Surviv. 2024 May 28. doi: 10.1007/s11764-024-01619-x.
8
Quality of Life Assessment Among Ethnically Diverse Black Prostate Cancer Survivors: A Constructivist Grounded Theory Approach.不同种族黑人前列腺癌幸存者的生活质量评估：一种建构主义扎根理论方法。
Res Sq. 2024 Feb 20:rs.3.rs-3941497. doi: 10.21203/rs.3.rs-3941497/v1.
9
Assessing racial, ethnic, and nativity disparities in US cancer mortality using a new integrated platform.利用新的综合平台评估美国癌症死亡率中的种族、民族和原籍国差异。
J Natl Cancer Inst. 2024 Jul 1;116(7):1145-1157. doi: 10.1093/jnci/djae052.
10
Dietary Plant Metabolites Induced Epigenetic Modification as a Novel Strategy for the Management of Prostate Cancer.饮食植物代谢物诱导的表观遗传修饰作为一种治疗前列腺癌的新策略。
Mini Rev Med Chem. 2024;24(15):1409-1426. doi: 10.2174/0113895575283895240207065454.
本文引用的文献
1
Clinical presentation and initial management of black men and white men with prostate cancer in the United Kingdom: the PROCESS cohort study.英国黑人男性和白人男性前列腺癌的临床表现和初步治疗：PROCESS 队列研究。
Br J Cancer. 2010 Jan 19;102(2):249-54. doi: 10.1038/sj.bjc.6605461. Epub 2009 Nov 24.
2
Screening and prostate-cancer mortality in a randomized European study.一项欧洲随机研究中的筛查与前列腺癌死亡率
N Engl J Med. 2009 Mar 26;360(13):1320-8. doi: 10.1056/NEJMoa0810084. Epub 2009 Mar 18.
3
Prostate cancer disparities in Black men of African descent: a comparative literature review of prostate cancer burden among Black men in the United States, Caribbean, United Kingdom, and West Africa.非洲裔美国黑人男性中的前列腺癌差异：对美国、加勒比、英国和西非的非洲裔美国黑人男性中前列腺癌负担的比较文献综述。
Infect Agent Cancer. 2009 Feb 10;4 Suppl 1(Suppl 1):S2. doi: 10.1186/1750-9378-4-S1-S2.
4
Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT).硒与维生素E对前列腺癌及其他癌症风险的影响：硒与维生素E癌症预防试验（SELECT）
JAMA. 2009 Jan 7;301(1):39-51. doi: 10.1001/jama.2008.864. Epub 2008 Dec 9.
5
Genome-wide association studies in cancer.癌症的全基因组关联研究。
Hum Mol Genet. 2008 Oct 15;17(R2):R109-15. doi: 10.1093/hmg/ddn287.
6
Pathways to diagnosis for Black men and White men found to have prostate cancer: the PROCESS cohort study.被诊断患有前列腺癌的黑人男性和白人男性的诊断途径：PROCESS队列研究。
Br J Cancer. 2008 Oct 7;99(7):1040-5. doi: 10.1038/sj.bjc.6604670. Epub 2008 Sep 16.
7
Investigating Black-White differences in prostate cancer prognosis: A systematic review and meta-analysis.研究前列腺癌预后方面的黑人和白人差异：一项系统评价和荟萃分析。
Int J Cancer. 2008 Jul 15;123(2):430-435. doi: 10.1002/ijc.23500.
8
Multiple newly identified loci associated with prostate cancer susceptibility.多个新发现的与前列腺癌易感性相关的基因座。
Nat Genet. 2008 Mar;40(3):316-21. doi: 10.1038/ng.90. Epub 2008 Feb 10.
9
Multiple loci identified in a genome-wide association study of prostate cancer.在一项前列腺癌全基因组关联研究中鉴定出多个基因座。
Nat Genet. 2008 Mar;40(3):310-5. doi: 10.1038/ng.91. Epub 2008 Feb 10.
10
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes.17号染色体上的两个变异体增加患前列腺癌的风险，而位于转录因子7类似物2（TCF2）基因中的那个变异体则可预防2型糖尿病。
Nat Genet. 2007 Aug;39(8):977-83. doi: 10.1038/ng2062. Epub 2007 Jul 1.
Zotero 插件