Department of Chemical & Biological Engineering, Princeton University, Princeton, New Jersey 08544, USA.
Nat Rev Mol Cell Biol. 2011 Aug 10;12(9):581-93. doi: 10.1038/nrm3168.
The mammary gland undergoes a spectacular series of changes as it develops, and maintains a remarkable capacity to remodel and regenerate for several decades. Mammary morphogenesis has been investigated for over 100 years, motivated by the dairy industry and cancer biologists. Over the past decade, the gland has emerged as a major model system in its own right for understanding the cell biology of tissue morphogenesis. Multiple signalling pathways from several cell types are orchestrated together with mechanical cues and cell rearrangements to establish the pattern of the mammary gland. The integrated mechanical and molecular pathways that control mammary morphogenesis have implications for the developmental regulation of other epithelial organs.
乳腺在发育和维持几十年的过程中经历了一系列壮观的变化，并且具有惊人的重塑和再生能力。乳腺形态发生已经被研究了 100 多年，其研究动力来自奶制品行业和癌症生物学家。在过去的十年中，乳腺已经成为一个独立的主要模型系统，用于理解组织形态发生的细胞生物学。来自多种细胞类型的多种信号通路与机械线索和细胞重排一起协调，以建立乳腺的模式。控制乳腺形态发生的整合机械和分子途径对其他上皮器官的发育调控具有重要意义。
