Blard J M, Rincon F, Nakache J P, Chastang C
Sem Hop. 1979;55(1-2):45-9.
One hundred and twelve subcutaneous injections of concentrated heparin (25,000 IU/ml), half in sodium heparin and half in calciparine, both with an identical heparin cation, were given in doses varying from 0.2 ml to 0.5 ml by a single operator in a double-blind study to assess the comparative local tolerance of the two heparin salts. The occurrence of bruising at the point of injection, more frequent with sodium heparin than with Calciparine, proved to be the distinguishing factor. Overall after 48 hours, 31 hematomas were observed with the sodium salt versus 20 with calciparine. McNemar's test of comparing matched proportions confirms this result (p = 0.03) and, with the order of the two treatments taken into consideration, J.J. Gart's exact test gives p = 0.0101.
在一项双盲研究中，由一名操作人员以0.2毫升至0.5毫升不等的剂量，对112例患者进行皮下注射浓缩肝素（25,000国际单位/毫升），其中一半使用肝素钠，另一半使用卡奇普明，两种药物的肝素阳离子相同，以评估这两种肝素盐的相对局部耐受性。注射部位出现瘀伤的情况，肝素钠比卡奇普明更常见，这被证明是区分两者的因素。48小时后，总体上，使用钠盐观察到31例血肿，而使用卡奇普明观察到20例。比较匹配比例的McNemar检验证实了这一结果（p = 0.03），并且考虑到两种治疗的顺序，J.J. Gart精确检验得出p = 0.0101。
