Billon N, Gloaguen F, Funck-Brentano C, Jaillon P
Clinical Pharmacology Unit, Saint-Antoine University Hospital, Paris, France.
Br J Clin Pharmacol. 1994 Apr;37(4):395-7. doi: 10.1111/j.1365-2125.1994.tb04296.x.
In order to compare the intensity and the duration of the pain following the subcutaneous injection of low molecular weight heparins, 0.4 ml nadroparin, 0.4 ml enoxaparin and 0.4 ml placebo (NaCl 0.9%) were administered at 1 week intervals to 12 healthy volunteers in a randomised, double-blind, three-period study. Pain was assessed by visual analogue and verbal category scales. Based on visual analogue scale scores, nadroparin resulted in significantly less pain than enoxaprin at 1 and 5 min after injection (6.2 +/- 2.6 mm vs 21.9 +/- 5.9 mm; P < 0.05 and 3.5 + 1.5 mm vs 14.3 +/- 4 mm; P < 0.05, respectively, mean +/- s.e. mean). Similar results were obtained using verbal category scale. Confidence interval testing for difference between groups showed that nadroparin injection resulted in less pain than enoxaparin at 1 min (-15.8: -31.2 to -0.4 mm).
为了比较皮下注射低分子量肝素后的疼痛强度和持续时间，在一项随机、双盲、三阶段研究中，每隔1周给12名健康志愿者皮下注射0.4 ml那屈肝素、0.4 ml依诺肝素和0.4 ml安慰剂（0.9%氯化钠溶液）。通过视觉模拟评分法和语言分类量表评估疼痛程度。根据视觉模拟评分法得分，注射后1分钟和5分钟时，那屈肝素引起的疼痛明显少于依诺肝素（分别为6.2±2.6 mm对21.9±5.9 mm；P<0.05以及3.5±1.5 mm对14.3±4 mm；P<0.05，均值±标准误均值）。使用语言分类量表也得到了类似结果。组间差异的置信区间检验显示，注射那屈肝素后1分钟时引起的疼痛少于依诺肝素（-15.8：-31.2至-0.4 mm）。
