Stone O J
Med Hypotheses. 1990 Feb;31(2):99-103. doi: 10.1016/0306-9877(90)90004-x.
Shortly after the introduction of sulfa drugs, sulfapyridine was found to have unique therapeutic properties, unrelated to antibacterial activity. Later, sulfones were found to share the same properties. The disorders initially improved were dermatitis herpetiformis, pyoderma gangrenosum, subcorneal pustular dermatosis, acrodermatitis continua, impetigo herpetiformis and ulcerative colitis. They were also sometimes helpful in many other disorders. They are effective in select disorders characterized by edema followed by granulocytic inflammation or edema followed by vesicle or bullae formation. The sulfones work in low doses in leprosy and their mode of action is not fully understood. Several pieces of experimental information are available. It is proposed that these drugs are entering or influencing the protein moiety of glycosaminoglycans and decreasing tissue viscosity. This decreased tissue viscosity prevents edema and dilution of tissue fluid and decreases acute inflammation and vesicle and bullae formation.
在磺胺类药物引入后不久，人们发现磺胺吡啶具有独特的治疗特性，与抗菌活性无关。后来，人们发现砜类药物也具有相同的特性。最初病情得到改善的疾病有疱疹样皮炎、坏疽性脓皮病、角层下脓疱性皮肤病、连续性肢端皮炎、疱疹样脓疱病和溃疡性结肠炎。它们有时对许多其他疾病也有帮助。它们对某些以水肿后粒细胞炎症或水肿后水疱或大疱形成为特征的疾病有效。砜类药物在麻风病治疗中低剂量有效，其作用方式尚未完全了解。有几条实验信息可供参考。有人提出，这些药物正在进入或影响糖胺聚糖的蛋白质部分，并降低组织粘度。这种降低的组织粘度可防止水肿和组织液稀释，并减少急性炎症以及水疱和大疱的形成。
