Kopple J D, Hirschberg R
Division of Nephrology and Hypertension, Harbor-UCLA Medical Center.
Miner Electrolyte Metab. 1990;16(1):82-8.
Growth hormone increases renal plasma flow and glomerular filtration rate and reduces total renal vascular resistance. Evidence presented in this paper indicates that these effects of growth hormone are mediated by insulin-like growth factor I (IGF-I). Published literature indicates that growth hormone and IGF-I have a number of other physiological and morphological effects on the kidney. Further studies are indicated to evaluate under which conditions growth hormone and IGF-I are regulators of kidney function, and to identify the mechanisms of action. In addition, the role of both hormones, if any, in the development of progressive glomerular sclerosis and renal failure needs to be explored.
生长激素可增加肾血浆流量和肾小球滤过率，并降低总肾血管阻力。本文提供的证据表明，生长激素的这些作用是由胰岛素样生长因子I（IGF-I）介导的。已发表的文献表明，生长激素和IGF-I对肾脏还有许多其他生理和形态学作用。需要进一步研究以评估生长激素和IGF-I在何种条件下是肾功能的调节因子，并确定其作用机制。此外，还需要探索这两种激素（如果有）在进行性肾小球硬化和肾衰竭发展过程中的作用。
