Simon Karen M, Carpes Marta F, Corrêa Krislainy S, dos Santos Karoliny, Karloh Manuela, Mayer Anamaria F
Departamento de Fisioterapia, Universidade Federal do Pampa (UNIPAMPA) , Uruguaiana, RS, Brasil.
Rev Bras Fisioter. 2011 May-Jun;15(3):212-8.
Chronic Obstructive Pulmonary Disease (COPD) is a progressive disease that reduces functional capacity, deteriorating the ability to perform activities of daily living (ADL). A close relationship between morbidity and mortality with functional limitation is observed in patients with COPD.
To determine if there is a relationship between ADL limitation and the BODE index, which is a predictor of mortality, in patients with moderate to severe COPD.
Thirty-nine patients with COPD GOLD 2 to 4 recruited by convenience, were submitted to the following tests: spirometry, body mass index (BMI), the London Chest Activity of Daily Living (LCADL) scale, six-minute walking test (6MWT), the Medical Research Council (MRC) scale and the BODE index was calculated. The total score and the percentage of the total score LCADL (LCADL%total) were compared between patients of the four quartiles of the BODE using the Analysis of Variance test. The Spearman correlation coefficient was used to investigate the association between scores of LCADL and BODE index.
Patients had an average of FEV1%pred=37±12% and were on average 66±8 years-old. The LCADL%total correlated with the BODE index (r=0.65, p<0.05) as well as with the variables FEV1, dyspnea and walked distance in the 6MWT (r=-0.42, r=0.76 and r=-0.67, p<0.05, respectively). The comparison of the average scores of the LCADL%total between BODE quartiles 1, 2, 3 and 4, demonstrated that only the 4th quartile differed significantly from the others (p<0.05).
ADL limitation has a strong association with the BODE index in patients with moderate to severe COPD and with three of the four variables that composes it.
慢性阻塞性肺疾病（COPD）是一种进行性疾病，会降低功能能力，使日常生活活动（ADL）能力恶化。在COPD患者中观察到发病率和死亡率与功能受限之间存在密切关系。
确定中重度COPD患者的ADL受限与作为死亡率预测指标的BODE指数之间是否存在关系。
通过便利抽样招募了39例GOLD 2至4级的COPD患者，进行以下测试：肺量计检查、体重指数（BMI）、伦敦胸部日常生活活动（LCADL）量表、六分钟步行试验（6MWT）、医学研究委员会（MRC）量表，并计算BODE指数。使用方差分析比较BODE四个四分位数患者的LCADL总分及LCADL总分百分比（LCADL%total）。采用Spearman相关系数研究LCADL评分与BODE指数之间的关联。
患者的FEV1%pred平均为37±12%，平均年龄为66±8岁。LCADL%total与BODE指数相关（r = 0.65，p<0.05），也与6MWT中的FEV1、呼吸困难和步行距离变量相关（分别为r = -0.42、r = 0.76和r = -0.67，p<0.05）。比较BODE四分位数1、2、3和4之间的LCADL%total平均得分，结果显示只有第4四分位数与其他四分位数有显著差异（p<0.05）。
中重度COPD患者的ADL受限与BODE指数以及构成该指数的四个变量中的三个有很强的关联。
