Department of Cardiovascular, Respiratory, Nephrology and Geriatric Sciences, Centre Glaucoma and Ocular Electrophysiology, Sapienza University of Rome, Rome, Italy.
J Ocul Pharmacol Ther. 2011 Dec;27(6):629-35. doi: 10.1089/jop.2010.0191. Epub 2011 Aug 10.
The purpose of this article was to evaluate whether the anti-inflammatory agent palmitoylethanolamide (PEA) can counteract the increase of intraocular pressure (IOP) that may occur after neodymium-doped: yttrium aluminum garnet (Nd:YAG) laser iridotomy.
Fifteen patients underwent bilateral laser iridotomy (Visulas YAG III Laser; Zeiss) for the prevention of primary closed-angle glaucoma. The IOP was measured at the beginning of the study (t-1), after 15 days of pretreatment with placebo or PEA (t0), and at 15, 30, and 120 min after the iridotomy (t1, t2, t3). The pretreatment consisted of 2 tablets of placebo or PEA per day for 15 days.
The t-test did not show a significant difference between the preoperative mean values of IOP t-1 and t0 in both the pretreatments. Analysis of variance/Tukey's test pointed out a significant increase of the postoperative IOP values in placebo pretreated patients (P≤0.05), but not in those who were pretreated with PEA. The trend analysis confirmed the significant positive trend in placebo pretreatment. The parallelism test between the 2 regressions showed a significant difference for the slopes (P=0.022) and not for the intercepts (P=0.520).
PEA can counteract the increase of IOP that occurs after iridotomy. It is likely that PEA controls the inflammatory process after iridotomy.
本文旨在评估抗炎剂棕榈酸乙醇酰胺（PEA）是否能对抗钕掺杂钇铝石榴石（Nd:YAG）激光虹膜切开术后可能发生的眼压（IOP）升高。
15 名患者接受双侧激光虹膜切开术（Visulas YAG III 激光；蔡司）以预防原发性闭角型青光眼。在研究开始时（t-1）、安慰剂或 PEA 预处理 15 天后（t0）以及虹膜切开后 15、30 和 120 分钟（t1、t2、t3）测量 IOP。预处理包括每天服用 2 片安慰剂或 PEA，持续 15 天。
t 检验显示，两种预处理的术前 IOP 值 t-1 和 t0 之间无显著差异。方差分析/Tukey 检验指出，安慰剂预处理患者术后 IOP 值显著升高（P≤0.05），但 PEA 预处理患者则无显著升高。趋势分析证实了安慰剂预处理的显著正趋势。两条回归之间的平行性检验显示斜率有显著差异（P=0.022），而截距无显著差异（P=0.520）。
PEA 可对抗虹膜切开术后 IOP 的升高。PEA 可能控制了虹膜切开后的炎症过程。
