Department of Pathophysiology, National Koranyi Institute of TB and Pulmonology, Piheno út 1, H-1121 Budapest, Hungary.
Lung Cancer. 2012 Feb;75(2):178-80. doi: 10.1016/j.lungcan.2011.07.007. Epub 2011 Aug 9.
Assessment of exhaled breath condensate (EBC) pH is a promising method for investigating and monitoring airway pathology in a number of lung diseases. In this cross-sectional study we tested whether development of lung cancer is associated with acidification of EBC. EBC was collected in 43 smoking patients with lung cancer (squamous cell carcinoma: 17 patients, adenocarcinoma: 16 patients, and small cell lung cancer: 10 patients) before receiving any anticancer treatment and in 20 healthy smokers without any clinical and radiological evidence of pulmonary tumor. EBC pH was measured by CO(2) gas standardization, the most reliable and accurate method at present. EBC pH in patients with pulmonary tumor (6.68±0.02) and in controls (6.63±0.05) was similar (p>0.05). Results were affected neither by the histological subtype nor the stage of the tumors. Our data suggest that assessment of EBC pH is of limited value for the diagnosis and/or screening of lung cancer.
呼出气冷凝液 (EBC) pH 值的评估是一种很有前途的方法，可用于研究和监测多种肺部疾病的气道病理变化。在这项横断面研究中，我们检测了肺癌的发生是否与 EBC 的酸化有关。在接受任何抗癌治疗之前，我们收集了 43 名患有肺癌（鳞状细胞癌：17 名患者，腺癌：16 名患者，小细胞肺癌：10 名患者）的吸烟患者的 EBC，并收集了 20 名没有任何肺部肿瘤临床和影像学证据的健康吸烟者的 EBC。通过 CO2 气体标准化来测量 EBC pH 值，这是目前最可靠和最准确的方法。肺部肿瘤患者的 EBC pH 值（6.68±0.02）和对照组的 EBC pH 值（6.63±0.05）相似（p＞0.05）。结果不受组织学亚型或肿瘤分期的影响。我们的数据表明，EBC pH 值的评估对于肺癌的诊断和/或筛查价值有限。
