Du Zhao-jie, Wang Lei, Lei De-lin, Liu Bao-lin, Cao Jian, Zhang Pu, Ma Qin
Department of Oral and Maxillofacial Surgery, Fourth Military Medical University, School of Stomatology, Xi'an 710032, China.
Br J Oral Maxillofac Surg. 2011 Oct;49(7):557-61. doi: 10.1016/j.bjoms.2011.07.002. Epub 2011 Aug 9.
Our aim was to find out if nerve growth factor (NGF) injected systemically could improve the recovery of the inferior alveolar nerve in a rabbit model of mandibular distraction osteogenesis. We used 48 New Zealand white rabbits that were treated with bilateral distraction osteogenesis at a rate of 0.5mm/12h for 10 days. Immediately postoperatively, NGF or sodium chloride 0.6 μg/day was injected intramuscularly for 20 days. At the end of distraction and after consolidation times of 1, 2, and 4 weeks, the inferior alveolar nerves were evaluated histologically and histomorphometrically. Histologically, at 2 and 4 weeks there was less myelin debris, and more regenerating axons were present, in the NGF than the control groups. The density of myelinated axons was significantly greater in groups with NGF than controls at 2 and 4 weeks (p<0.05). NGF given systemically can accelerate the recovery of the inferior alveolar nerve in rabbits after mandibular distraction osteogenesis, and is a promising treatment option for neurological complications of mandibular distraction osteogenesis.
我们的目的是探究全身注射神经生长因子（NGF）是否能促进兔下颌骨牵张成骨模型中下颌神经的恢复。我们使用了48只新西兰白兔，对其双侧进行牵张成骨，牵张速率为0.5mm/12小时，持续10天。术后立即肌肉注射NGF或0.6μg/天的氯化钠，持续20天。在牵张结束时以及巩固1、2和4周后，对下颌神经进行组织学和组织形态计量学评估。组织学上，在2周和4周时，与对照组相比，NGF组的髓磷脂碎片更少，再生轴突更多。在2周和4周时，NGF组有髓轴突的密度显著高于对照组（p<0.05）。全身给予NGF可加速兔下颌骨牵张成骨后下颌神经的恢复，是治疗下颌骨牵张成骨神经并发症的一种有前景的治疗选择。
