Yao Yang, Du Yu, Gu Xia, Guang Meng-Kai, Huang Bo, Gong Ping
State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Hua Xi Kou Qiang Yi Xue Za Zhi. 2018 Apr 1;36(2):128-132. doi: 10.7518/hxkq.2018.02.003.
To investigate the effects of nerve growth factor (NGF) in the osteogenic action of implants and the maturation and reconstruction changes in bone tissues in the early stage of osseointegration.
The mouse implant model was established by placing titanium in the femoral head of the mouse and locally injecting NGF in the implant zone. On 1, 2 and 4 weeks after operation, stain samples were collected from animals using hematoxylin-eosin (HE) staining and Masson staining. The effect of NGF on the bone maturation was compared at different time points of early stage osseointegration.
The results of HE and Masson staining indicated that the local injection of external NGF can up-regulate bone mass, amount of bone trabecula, and bone maturity in the mouse model. The mature bone rate in treatment group of 1 week and 4 weeks after operation were significantly higher than those in the control group (P<0.05).
NGF can shorten the period of bone maturation.
探讨神经生长因子（NGF）在种植体成骨作用及骨结合早期骨组织成熟与改建变化中的作用。
通过将钛植入小鼠股骨头并在种植区局部注射NGF建立小鼠种植模型。术后1、2和4周，采用苏木精-伊红（HE）染色和Masson染色从动物体内采集染色样本。在骨结合早期的不同时间点比较NGF对骨成熟的影响。
HE染色和Masson染色结果表明，局部注射外源性NGF可上调小鼠模型中的骨量、骨小梁数量和骨成熟度。术后1周和4周治疗组的成熟骨率显著高于对照组（P<0.05）。
NGF可缩短骨成熟时间。
