Department of Medical Psychology, Leiden University Medical Centre, PO Box 9600, Room J6-124, 2300 RC Leiden, The Netherlands.
Early Hum Dev. 2011 Sep;87(9):589-93. doi: 10.1016/j.earlhumdev.2011.07.003. Epub 2011 Aug 9.
The long-term neurodevelopmental outcome of children born after intrauterine blood transfusion (IUT) for red cell alloimmunization is considered favorable. Severe hydrops has been identified as a strong predictor for neurodevelopmental impairment. However, the long-term outcome of survivors of IUT for congenital Parvovirus B19 infection and fetomaternal hemorrhage is not well known. Limitations of the follow-up studies to date are small sample size, lack of controls, unclear criteria for impairment and lack of standardized developmental tests. Future research should take into account more subtle impairments, since cognitive functioning <-1 SD, behavioral and learning problems already have a significant impact on care requirements and future socio-economic potential. A better understanding of the effect of IUT and fetal anemia on child development over time will allow more accurate parental counseling and targeted interventions to optimize child development when needed.
对于因红细胞同种免疫而接受宫内输血 (IUT) 的儿童，其长期神经发育结局被认为是良好的。严重胎儿水肿已被确定为神经发育障碍的强烈预测因素。然而，先天性细小病毒 B19 感染和胎儿-母体出血的 IUT 幸存者的长期结局尚不清楚。迄今为止，随访研究的局限性在于样本量小、缺乏对照、损害标准不明确以及缺乏标准化的发育测试。未来的研究应考虑到更细微的损伤，因为认知功能 <-1 SD、行为和学习问题已经对护理需求和未来的社会经济潜力产生重大影响。更好地了解 IUT 和胎儿贫血对儿童随时间发展的影响，将允许更准确的父母咨询和有针对性的干预措施，以在需要时优化儿童的发育。
