Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Tuberculosis (Edinb). 2011 Sep;91(5):386-9. doi: 10.1016/j.tube.2011.07.003. Epub 2011 Aug 9.
Clinical reports suggest an association of distinct Mycobacterium tuberculosis strains with CNS disease. We therefore examined CNS dissemination by different laboratory strains (two M. tuberculosis H37Rv, one CDC1551) in a guinea pig aerosol infection model. Although all strains grew exponentially in lungs, with similar bacterial burdens at the time of extrapulmonary dissemination, M. tuberculosis CDC1551 disseminated to the CNS significantly more than the H37Rv strains. No CNS lesions were observed throughout the study, with only a modest cytokine response. These data suggest that M. tuberculosis may have virulence factors that promote CNS dissemination, distinct from those required for pulmonary TB.
临床报告表明，特定的结核分枝杆菌菌株与中枢神经系统疾病有关。因此，我们在豚鼠气溶胶感染模型中研究了不同实验室菌株（两种结核分枝杆菌 H37Rv、一种 CDC1551）对中枢神经系统的传播。尽管所有菌株在肺部呈指数级生长，在肺外传播时具有相似的细菌负荷，但结核分枝杆菌 CDC1551 向中枢神经系统的传播明显多于 H37Rv 菌株。在整个研究过程中未观察到中枢神经系统病变，只有适度的细胞因子反应。这些数据表明，结核分枝杆菌可能具有促进中枢神经系统传播的毒力因子，与引起肺结核的毒力因子不同。
