Kanda Souhei, Inoue Takamitsu, Tsuruta Hiroshi, Chiba Shuji, Obara Takashi, Saito Mitsuru, Kumazawa Teruaki, Tsuchiya Norihiko, Satoh Shigeru, Habuchi Tomonori
The Department of Urology, School of Medicine, Akita University.
Hinyokika Kiyo. 2011 Jul;57(7):385-9.
A 62-year-old female patient with a chief complaint of back pain and continuous fever was referred to our hospital. A computed tomography scan revealed a left renal tumor (76×54×67 mm) without a metastatic lesion. Laboratory examination showed an elevated white blood cell count of 23,200/μl. The patient underwent left radical nephrectomy and the histopathological diagnosis was spindle cell renal cell carcinoma (G3-4, pT4, pN2) with positive staining for granulocyte colony-stimulating factor. One month later, a computed tomography scan showed an enlarged locally recurrent tumor mass. Three cycles of combination chemotherapy consisting of gemcitabine (1,500 mg/m2, day 1) and doxorubicine (50 mg/m2, day 1) resulted in an 83% reduction of the tumor mass. A follow-up computed tomography scan after 2 weeks revealed rapid regrowth of the recurrent tumor. The patient died 199 days after the surgery. Combination chemotherapy consisting of gemcitabine and doxorubicin is a treatment option for patients with spindle cell renal cell carcinoma.
一名62岁女性患者，以背痛和持续发热为主诉转诊至我院。计算机断层扫描显示左肾肿瘤（76×54×67mm），无转移灶。实验室检查显示白细胞计数升高至23,200/μl。患者接受了左肾根治性切除术，组织病理学诊断为梭形细胞肾细胞癌（G3 - 4，pT4，pN2），粒细胞集落刺激因子染色呈阳性。1个月后，计算机断层扫描显示局部复发性肿瘤肿块增大。吉西他滨（1500mg/m²，第1天）和阿霉素（50mg/m²，第1天）联合化疗3个周期后，肿瘤肿块缩小了83%。2周后的随访计算机断层扫描显示复发性肿瘤迅速再生。患者术后199天死亡。吉西他滨和阿霉素联合化疗是梭形细胞肾细胞癌患者的一种治疗选择。
