Kato Taigo, Oida Takeshi, Otoshi Taiyo, Katayama Kinzo, Kobayashi Kenichi, Tei Norihide, Takada Shingo, Matsumiya Kiyomi
The Department of Urology, Osaka Police Hospital.
Hinyokika Kiyo. 2011 Jul;57(7):399-401.
Bilateral anorchia is defined as the complete absence of testicular tissue with a normal male karyotype and phenotype. Although the precise etiology is not well understood, mechanical causes during or after testicular descent have been suggested, while genetic factors have also been reported. We treated a patient with bilateral anorchia who obtained excellent growth bytestosterone replacement therapyas compared with his normal identical twin. The patient was diagnosed with negative elevation of testosterone after hCG administration and surgical exploration confirmed the absence of a testicular structure. We began testosterone replacement therapyfrom 13 years old with the goal of matching the development of his brother. Four months after initiating therapy, the patient showed voice breaking and pubic hair growth. Thereafter, there were scant differences in height and secondarysexual characteristics as compared with his brother.
双侧无睾症的定义为具有正常男性核型和表型但完全没有睾丸组织。尽管确切病因尚不完全清楚，但有观点认为是睾丸下降过程中或之后的机械性原因导致的，同时也有遗传因素的报道。我们治疗了一名双侧无睾症患者，与他的同卵双胞胎兄弟相比，通过睾酮替代疗法他获得了良好的生长发育。该患者在注射人绒毛膜促性腺激素（hCG）后睾酮水平呈阴性升高，手术探查证实没有睾丸结构。我们从患者13岁开始进行睾酮替代疗法，目标是使其发育与他的兄弟相匹配。开始治疗四个月后，患者出现了声音变粗和阴毛生长。此后，与他的兄弟相比，身高和第二性征方面几乎没有差异。
