Department of Cell Biology and Anatomy, Hotchkiss Brain Institute, University of Calgary, Calgary, AB Canada.
Channels (Austin). 2011 Sep-Oct;5(5):440-8. doi: 10.4161/chan.5.5.16473. Epub 2011 Sep 1.
Voltage gated calcium channels are key mediators of depolarization induced calcium entry into electrically excitable cells. There is increasing evidence that voltage gated calcium channels, like many other types of ionic channels, do not operate in isolation, but instead forms signaling complexes with signaling molecules, G protein coupled receptors, and other types of ion channels. Furthermore, there appears to be bidirectional signaling within these protein complexes, thus allowing not only for efficient translation of calcium signals into cellular responses, but also for tight control of calcium entry per se. In this review, we will focus predominantly on signaling complexes between G protein-coupled receptors and high voltage activated calcium channels, and on complexes of voltage-gated calcium channels and members of the potassium channel superfamily.
电压门控钙通道是去极化诱导可兴奋细胞内钙离子内流的主要介质。越来越多的证据表明，电压门控钙通道与许多其他类型的离子通道一样，并非孤立运作，而是与信号分子、G 蛋白偶联受体和其他类型的离子通道形成信号复合物。此外，这些蛋白质复合物内似乎存在双向信号传递，因此不仅可以将钙信号有效地转化为细胞反应，还可以对钙内流本身进行严格控制。在这篇综述中，我们将主要关注 G 蛋白偶联受体和高电压激活钙通道之间的信号复合物，以及电压门控钙通道和钾通道超家族成员之间的复合物。
