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Experimental therapies for Parkinson's disease: Why fake it?

作者信息

Katsnelson Alla

出版信息

Nature. 2011 Aug 10;476(7359):142-4. doi: 10.1038/476142a.

DOI:10.1038/476142a
PMID:21833065
Abstract
摘要

相似文献

1
Experimental therapies for Parkinson's disease: Why fake it?帕金森病的实验性疗法：为何要造假？
Nature. 2011 Aug 10;476(7359):142-4. doi: 10.1038/476142a.
2
Placebos that harm: sham surgery controls in clinical trials.有害的安慰剂：临床试验中的假手术对照
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Preparing for a post-placebo paradigm: ethics and choice of control in clinical trials.为后安慰剂范式做准备：临床试验中的伦理与对照选择
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Placebo misconceptions.安慰剂误解。
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Research, medicine, and "placebos".研究、医学与“安慰剂”。
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Placebo: its action and place in health research today--summary and conclusions.安慰剂：其作用及在当今健康研究中的地位——总结与结论
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Conflating scientific with clinical considerations.将科学考量与临床考量混为一谈。
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引用本文的文献

1
Evidence-Based Evaluation of the Ethics of Sham Surgery for Parkinson's Disease.基于证据的假性帕金森手术伦理评估。
J Parkinsons Dis. 2019;9(3):565-574. doi: 10.3233/JPD-191577.
2
Differentiation of adult human retinal pigment epithelial cells into dopaminergic-like cells in vitro and in the recipient monkey brain.体外诱导人视网膜色素上皮细胞向多巴胺能样细胞分化及其在受体猴脑中的分化。
Mol Med. 2019 Mar 29;25(1):9. doi: 10.1186/s10020-019-0076-3.
3
Differential behavioral outcomes following neonatal versus fetal human retinal pigment epithelial cell striatal implants in parkinsonian rats.

本文引用的文献

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Intrastriatal transplantation of microcarrier-bound human retinal pigment epithelial cells versus sham surgery in patients with advanced Parkinson's disease: a double-blind, randomised, controlled trial.立体定向纹状体移植微载体结合的人视网膜色素上皮细胞与假手术治疗晚期帕金森病患者的随机双盲对照研究。
Lancet Neurol. 2011 Jun;10(6):509-19. doi: 10.1016/S1474-4422(11)70097-7. Epub 2011 May 10.
2
AAV2-GAD gene therapy for advanced Parkinson's disease: a double-blind, sham-surgery controlled, randomised trial.AAV2-GAD 基因治疗晚期帕金森病：一项双盲、假手术对照、随机试验。
Lancet Neurol. 2011 Apr;10(4):309-19. doi: 10.1016/S1474-4422(11)70039-4.
3
帕金森病大鼠中新生与胎儿人类视网膜色素上皮细胞纹状体植入后的不同行为结果
J Neural Transm (Vienna). 2017 Apr;124(4):455-462. doi: 10.1007/s00702-017-1683-1. Epub 2017 Feb 4.
4
Network modulation following sham surgery in Parkinson's disease.帕金森病假手术后的网络调节
J Clin Invest. 2014 Aug;124(8):3656-66. doi: 10.1172/JCI75073. Epub 2014 Jul 18.
5
When norepinephrine becomes a driver of breathing irregularities: how intermittent hypoxia fundamentally alters the modulatory response of the respiratory network.当去甲肾上腺素成为呼吸不规则的驱动因素时：间歇性低氧如何从根本上改变呼吸网络的调节反应。
J Neurosci. 2014 Jan 1;34(1):36-50. doi: 10.1523/JNEUROSCI.3644-12.2014.
6
The potential benefit of the placebo effect in sham-controlled trials: implications for risk-benefit assessments and informed consent.安慰剂效应在假对照试验中的潜在益处：对风险效益评估和知情同意的影响。
J Med Ethics. 2013 Nov;39(11):703-7. doi: 10.1136/medethics-2012-101045. Epub 2012 Dec 13.
7
Sham surgery controls in Parkinson's disease clinical trials: views of participants.帕金森病临床试验中的假手术对照：参与者的观点。
Mov Disord. 2012 Sep 15;27(11):1461-5. doi: 10.1002/mds.25155. Epub 2012 Aug 23.
Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial.
AAV2-神经生长因子基因治疗帕金森病：一项双盲、随机、对照试验。
Lancet Neurol. 2010 Dec;9(12):1164-1172. doi: 10.1016/S1474-4422(10)70254-4. Epub 2010 Oct 20.
4
Serotonergic neurons mediate dyskinesia side effects in Parkinson's patients with neural transplants.血清素能神经元介导帕金森病患者神经移植后的运动障碍副作用。
Sci Transl Med. 2010 Jun 30;2(38):38ra46. doi: 10.1126/scitranslmed.3000976.
5
Spheramine for treatment of Parkinson's disease.用于治疗帕金森病的司来吉兰
Neurotherapeutics. 2008 Apr;5(2):252-9. doi: 10.1016/j.nurt.2008.02.006.
6
Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2-neurturin) to patients with idiopathic Parkinson's disease: an open-label, phase I trial.向特发性帕金森病患者脑内注射CERE-120（腺相关病毒2型-神经营养因子）的安全性和耐受性：一项开放标签的I期试验。
Lancet Neurol. 2008 May;7(5):400-8. doi: 10.1016/S1474-4422(08)70065-6. Epub 2008 Apr 2.
7
Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trial.携带谷氨酸脱羧酶（GAD）基因的腺相关病毒（AAV）基因疗法治疗帕金森病的安全性和耐受性：一项开放标签的I期试验。
Lancet. 2007 Jun 23;369(9579):2097-105. doi: 10.1016/S0140-6736(07)60982-9.
8
Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease.帕金森病中脑内注射胶质细胞源性神经营养因子的随机对照试验。
Ann Neurol. 2006 Mar;59(3):459-66. doi: 10.1002/ana.20737.
9
Science and ethics of sham surgery: a survey of Parkinson disease clinical researchers.假手术的科学与伦理：帕金森病临床研究人员的调查
Arch Neurol. 2005 Sep;62(9):1357-60. doi: 10.1001/archneur.62.9.1357.
10
Effects of perceived treatment on quality of life and medical outcomes in a double-blind placebo surgery trial.双盲安慰剂手术试验中感知治疗对生活质量和医疗结局的影响。
Arch Gen Psychiatry. 2004 Apr;61(4):412-20. doi: 10.1001/archpsyc.61.4.412.